Lototskaya Polina S, Manina Marina A, Tertychnyy Aleksandr S, Zamyatnin Andrey A, Erdes Svetlana I
Filatov Clinical Institute of Child Health, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Department of Pathological Anatomy, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Diagnostics (Basel). 2020 Jan 9;10(1):31. doi: 10.3390/diagnostics10010031.
Coeliac disease (CD) is a gluten-dependent inflammatory disease of the small bowel that affects up to 1% of the global population. Herein, the presence of ulcers, erosions, or strictures in the duodenum for non-advanced cases of CD is a rarity. Case report: We present a clinical case of a 17-year-old girl, who from the age of 9, had suffered from erosive (HP)-associated gastritis and erosive duodenitis. At 16, she was diagnosed with a duodenal ulcer, complicated by cicatricial deformity of the bulb. While an atypical course in the development of the disease had led to the initial delay in diagnosis, a serum study and an intestinal biopsy confirmed CD. Discussion: A recent study found an elevated rate of peptic ulcer disease in patients with CD. From literature searches, comorbid HP infection and CD have indeed been widely reported, whereas cases highlighting the prevalence of CD-associated peptic ulcers have been observed and reported in only a few instances. Consequently, greater awareness is warranted and must be exercised for identifying the origins of ulcerative lesions that may be CD-related or -derived.
乳糜泻（CD）是一种依赖麸质的小肠炎症性疾病，全球患病率高达1%。在非进展期CD病例中，十二指肠出现溃疡、糜烂或狭窄的情况较为罕见。病例报告：我们呈现了一名17岁女孩的临床病例，她从9岁起就患有糜烂性（幽门螺杆菌相关性）胃炎和糜烂性十二指肠炎。16岁时，她被诊断出患有十二指肠溃疡，并伴有球部瘢痕性畸形。虽然疾病发展过程中的非典型病程导致了最初的诊断延迟，但血清学检查和肠道活检确诊为CD。讨论：最近一项研究发现，CD患者的消化性溃疡疾病发生率有所升高。通过文献检索发现，幽门螺杆菌合并感染和CD确实已有广泛报道，而突出CD相关性消化性溃疡患病率的病例仅在少数情况下被观察和报道过。因此，有必要提高认识，并在识别可能与CD相关或由CD引起的溃疡性病变的病因时保持警惕。
