Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, No 193 Tunxi Road, Hefei 230009, People's Republic of China; School of Food and Biological Engineering, Hefei University of Technology, No 193 Tunxi Road, Hefei 230009, People's Republic of China.
School of Food and Biological Engineering, Hefei University of Technology, No 193 Tunxi Road, Hefei 230009, People's Republic of China.
Carbohydr Polym. 2020 Mar 15;232:115810. doi: 10.1016/j.carbpol.2019.115810. Epub 2019 Dec 30.
In the present work, lotus root amylopectin (LRA)-chitosan (CS) composite hydrogel was developed as a delivery system for curcumin (CUR). Results exhibited that a stable LRA-CS-CUR hydrogel was formed using LRA and CS in the ratio of 3:2 (w/w) at pH 4.0. Under this condition, the particle size, polydispersity index and zeta potential of the LRA-CS-CUR was 410.3 nm, 0.211 and +26.47 mV, respectively. The analysis of transmission electron microscopy, fourier transform infrared spectroscopy and X-ray diffractometer revealed that curcumin was successfully encapsulated in the LRA-CS hydrogel, giving a high encapsulation efficiency of 90.3 %. Moreover, this composite hydrogel could significantly improve the solubility and stability of curcumin. The release characteristics of encapsulated curcumin in simulated gastric fluid and simulated intestinal fluid were further investigated. Results exhibited that the LRA-CS hydrogel enabled curcumin to be stable in stomach and release in small intestine.
在本工作中，开发了一种莲藕直链淀粉（LRA）-壳聚糖（CS）复合水凝胶作为姜黄素（CUR）的递送系统。结果表明，在 pH 4.0 下，LRA 和 CS 的比例为 3:2（w/w）时可形成稳定的 LRA-CS-CUR 水凝胶。在此条件下，LRA-CS-CUR 的粒径、多分散指数和 Zeta 电位分别为 410.3nm、0.211 和+26.47mV。透射电子显微镜、傅里叶变换红外光谱和 X 射线衍射仪的分析表明，姜黄素成功地包封在 LRA-CS 水凝胶中，包封效率高达 90.3%。此外，这种复合水凝胶可以显著提高姜黄素的溶解度和稳定性。进一步研究了模拟胃液和模拟肠液中包封姜黄素的释放特性。结果表明，LRA-CS 水凝胶使姜黄素在胃中稳定，并在小肠中释放。
