人类谷胱甘肽S-转移酶pi基因的结构
The structure of the human glutathione S-transferase pi gene.
作者信息
Cowell I G, Dixon K H, Pemble S E, Ketterer B, Taylor J B
机构信息
Cancer Research Campaign Molecular Toxicology Research Group, University College and Middlesex School of Medicine, London, U.K.
出版信息
Biochem J. 1988 Oct 1;255(1):79-83. doi: 10.1042/bj2550079.
The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.
人谷胱甘肽S-转移酶π基因已从黏粒文库中分离出来。该基因跨度约3kb，被6个内含子打断，其5'端周围区域具有HTF（HpaII小片段）岛典型的高G + C和CpG含量。除了在相对于转录起始位点-28位置处的TATA盒和两个G + C盒（GGGCGG）外，启动子还包含一个与多瘤病毒增强子中佛波酯和ras反应元件相匹配的序列基序。
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