Dickey Ryan M, Hembd Austin S, Fruge Seth, Haddock Nicholas T, Papas Klearchos K, Suszynski Thomas M
From the Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
Department of Surgery, Institute of Cellular Transplantation, University of Arizona, Tucson, AZ.
Ann Plast Surg. 2020 Jun;84(6):711-716. doi: 10.1097/SAP.0000000000002194.
Composite tissue (CT) preservation is important to outcomes after replant or transplant. Since the first limb replant, the mainstay of preservation has been static cold storage with the amputated part being placed in moistened gauze over ice. Historically, the gold-standard in solid organ preservation has been static cold storage with specialized solution, but this has recently evolved in the last few decades to develop technologies such as machine perfusion and even persufflation. This review explores the impact of cooling and oxygenation on CT, summarizes the work done in the area of CT preservation, discusses lessons learned from our experience in solid organ preservation, and proposes future directions.
