Tysnes Kristoffer Relling, Angell Inga Leena, Fjellanger Iselin, Larsen Sigrid Drageset, Søfteland Silje Rebekka, Robertson Lucy J, Skancke Ellen, Rudi Knut
Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.B. 369 Sentrum, 0102 Oslo, Norway.
Department of Chemistry, Biotechnology and Food science (IKBM), Norwegian University of Life Sciences, 1430, Box 5003 Ås, Norway.
Animals (Basel). 2020 Jan 25;10(2):204. doi: 10.3390/ani10020204.
Although our understanding of the role of the gut microbiota in different diseases is improving, our knowledge regarding how the gut microbiota affects functioning in healthy individuals is still limited. Here, we hypothesize that the gut microbiota could be associated with sled dog endurance-race performance. We investigated the gut microbiota in 166 fecal samples from 96 Alaskan Huskies, representing 16 teams participating in the 2016 Femund Race (400 km) in Norway, relating the microbiota composition to performance and metadata derived from questionnaires. For 16S rRNA gene sequencing-derived compositional data, we found a strong negative association between (dysbiosis-associated) and (normobiosis-associated) The teams with the best performances showed both the lowest levels of dysbiosis-associated bacteria prior to the race and the lowest change (decrease) in these bacteria after the race. Taken together, our results support the hypothesis that normobiosis-associated bacteria are involved in resilience mechanisms, potentially preventing growth of during the race.
尽管我们对肠道微生物群在不同疾病中的作用的理解正在不断提高，但我们对肠道微生物群如何影响健康个体功能的了解仍然有限。在此，我们假设肠道微生物群可能与雪橇犬耐力赛成绩有关。我们调查了来自96只阿拉斯加哈士奇的166份粪便样本中的肠道微生物群，这些样本代表了参加2016年挪威费蒙德400公里比赛的16支队伍，将微生物群组成与成绩以及从问卷中获得的元数据相关联。对于16S rRNA基因测序得出的组成数据，我们发现（与失调相关的）和（与正常微生物群相关的）之间存在强烈的负相关。表现最佳的队伍在比赛前失调相关细菌水平最低，比赛后这些细菌的变化（减少）也最小。综上所述，我们的结果支持以下假设：与正常微生物群相关的细菌参与了恢复机制，可能在比赛期间阻止了的生长。
