Laboratório de Bioquímica e Microbiologia Aplicada, Departamento de Ciência de Alimentos, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Crit Rev Biotechnol. 2020 May;40(3):306-319. doi: 10.1080/07388551.2019.1710457. Epub 2020 Jan 28.
The marine environment encompasses a huge biological diversity and can be considered as an underexplored location for prospecting bioactive molecules. In this review, the current state of art about antimicrobial molecules from marine bacteria has been summarized considering the main phylum and sources evolved in a marine environment. Considering the last two decades, we have found as most studied group of bacteria producers of substances with antimicrobial activity is the Firmicutes phylum, in particular strains of the genus. The reason for that can be attributed to the difficult cultivation of typical Actinobacteria from a marine sediment, whose members are the major producers of antimicrobial substances in land environments. However, a reversed trend has been observed in recent years with an increasing number of reports settling on Actinobacteria. Great diversity of chemical structures have been identified, such as fijimicyns and lynamicyns from Actinomycetes and macrolactins produced by .
海洋环境包含了巨大的生物多样性,可以被视为一个尚未充分探索的地方,用于寻找具有生物活性的分子。在这篇综述中,考虑到在海洋环境中进化的主要门和来源,总结了海洋细菌来源的抗菌分子的最新研究进展。在过去的二十年中,我们发现研究最多的具有抗菌活性物质产生菌的细菌是厚壁菌门,特别是属的菌株。其原因可以归因于海洋沉积物中典型放线菌的难以培养,而放线菌是陆地环境中抗菌物质的主要产生者。然而,近年来出现了一个相反的趋势,越来越多的报道集中在放线菌上。已经鉴定出了许多化学结构的多样性,如放线菌产生的 fijimicyns 和 lynamicyns 以及产生的大环内酯。