Liu Yue, Liang Zhengjiao, Shi Jingya, Lin Xiaonan, Jiang Puzi, Sun Haoyuan, Chen Fengling, Yue Zhen, Fang Xiaodong, Hu Yonghua, Chen Haixin
BGI Research, Sanya, 572025, China.
Hainan Technology Innovation Center for Marine Biological Resources Utilization (Preparatory Period), BGI Research, Sanya, 572025, China.
Sci Data. 2025 Jul 15;12(1):1225. doi: 10.1038/s41597-025-05567-8.
Actinomycetes are a highly diverse group of microorganisms that have long been recognized as a valuable source of antibiotics and other bioactive metabolites. Recent advances in genome mining have revealed a wealth of previously unexplored silent secondary metabolite biosynthetic gene clusters (smBGCs) in actinomycete genomes, underscoring their untapped bioactivity potential. Here, we present the genome sequences of 211 actinomycete strains isolated from various environmental sources, generated through high-throughput sequencing. The resulting genome assemblies exhibit high completeness and accuracy, offering high-quality data for downstream analyses and biological resource exploration.
放线菌是一类高度多样化的微生物，长期以来一直被认为是抗生素和其他生物活性代谢物的宝贵来源。基因组挖掘的最新进展揭示了放线菌基因组中大量以前未被探索的沉默次生代谢物生物合成基因簇（smBGCs），突出了它们尚未开发的生物活性潜力。在这里，我们展示了通过高通量测序从各种环境来源分离的211株放线菌菌株的基因组序列。所得的基因组组装显示出高完整性和准确性，为下游分析和生物资源探索提供了高质量的数据。
