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肥胖类型与常见血管及代谢性疾病之间的关联:一项横断面研究。

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study.

作者信息

Zhang Peng, Sun Xin, Jin Hang, Zhang Fu-Liang, Guo Zhen-Ni, Yang Yi

机构信息

Clinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun, China.

Department of Neurology, The First Hospital of Jilin University, Changchun, China.

出版信息

Front Endocrinol (Lausanne). 2020 Jan 9;10:900. doi: 10.3389/fendo.2019.00900. eCollection 2019.

Abstract

The association between different types of obesity and some chronic diseases in Dehui, Jilin province, China, is still unclear. The aim of our study was to clarify the association between different types of obesity and chronic diseases. Residents aged 40 years or older were randomly selected using a multistage stratified cluster sampling method. Data were collected by means of face-to-face interview, physical examination, and laboratory examination. Descriptive data analyses were performed, and multiple logistic regression analyses were used to explore the adjusted association between different types of obesity and common vascular and metabolic diseases. The prevalence of general obesity alone, central obesity alone and compound obesity were 0.15, 54.29, and 14.36%, respectively. The prevalence of coronary heart disease, stroke, hypertension, dyslipidemia, and diabetes mellitus was highest in the compound obesity group, and lowest in the non-obesity group. Hypertension, dyslipidemia, and diabetes mellitus were associated with compound obesity and central obesity alone [compound obesity (OR = 4.703, 95% CI: 3.714-5.956 for hypertension; OR = 4.244, 95% CI: 3.357-5.365 for dyslipidemia; OR = 4.575, 95% CI: 3.194-6.552 for diabetes mellitus); central obesity alone (OR = 2.210, 95% CI: 1.901-2.570 for hypertension; OR = 2.598, 95% CI: 2.241-3.012 for dyslipidemia; OR = 2.519, 95% CI: 1.834-3.459 for diabetes mellitus)]. Coronary heart disease was associated with compound obesity (OR = 1.761, 95% CI: 1.141-2.719) but not central obesity alone (OR = 1.409, 95% CI: 0.986-2.013). Stroke was associated with neither compound obesity (OR = 1.222, 95% CI: 0.815-1.833) nor associated with central obesity alone (OR = 1.080, 95% CI: 0.786-1.485). Central obesity alone and compound obesity are associated with the risk of hypertension, hyperlipidemia, and diabetes mellitus. Compound obesity but not central obesity alone is associated with the risk of coronary heart disease, but further research is needed to confirm it. There are no significant relationship between stroke and central obesity alone or compound obesity.

摘要

中国吉林省德惠市不同类型肥胖与某些慢性疾病之间的关联仍不明确。我们研究的目的是阐明不同类型肥胖与慢性疾病之间的关联。采用多阶段分层整群抽样方法随机选取40岁及以上居民。通过面对面访谈、体格检查和实验室检查收集数据。进行描述性数据分析,并采用多元逻辑回归分析探讨不同类型肥胖与常见血管和代谢疾病之间的校正关联。单纯性全身肥胖、单纯性中心性肥胖和复合型肥胖的患病率分别为0.15%、54.29%和14.36%。复合型肥胖组冠心病、中风、高血压、血脂异常和糖尿病的患病率最高,非肥胖组最低。高血压、血脂异常和糖尿病与复合型肥胖及单纯性中心性肥胖相关[复合型肥胖(高血压:OR = 4.703,95%CI:3.714 - 5.956;血脂异常:OR = 4.244,95%CI:3.357 - 5.365;糖尿病:OR = 4.575,95%CI:3.194 - 6.552);单纯性中心性肥胖(高血压:OR = 2.210,95%CI:1.901 - 2.570;血脂异常:OR = 2.598,95%CI:2.241 - 3.012;糖尿病:OR = 2.519,95%CI:1.834 - 3.459)]。冠心病与复合型肥胖相关(OR = 1.761,95%CI:1.141 - 2.719),但与单纯性中心性肥胖无关(OR = 1.409,95%CI:0.986 - 2.013)。中风与复合型肥胖(OR = 1.222,95%CI:0.815 - 1.833)及单纯性中心性肥胖均无关(OR = 1.080,95%CI:0.786 - 1.485)。单纯性中心性肥胖和复合型肥胖与高血压、高脂血症和糖尿病风险相关。复合型肥胖而非单纯性中心性肥胖与冠心病风险相关,但需要进一步研究加以证实。中风与单纯性中心性肥胖或复合型肥胖均无显著关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/595f/6962099/5fc2e1e45490/fendo-10-00900-g0001.jpg

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