Nomura H, Kashiwagi S, Hayashi J, Kajiyama W, Ikematsu H, Noguchi A, Tani S, Goto M
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Am J Epidemiol. 1988 Aug;128(2):277-84. doi: 10.1093/oxfordjournals.aje.a114968.
A total of 932 hepatitis B surface antigen (HBsAg) carriers and 1,704 HBsAg-negative inhabitants of the Yaeyama District of Okinawa, Japan, over age 20 years were investigated in 1982-1985 in order to elucidate whether an interaction between habitual alcohol intake and hepatitis B virus infection is capable of producing liver disease. All of the subjects were tested for biochemical liver functions and asked about their habitual intake of alcohol. HBsAg carriers were tested for hepatitis B e antigen (HBeAg) and antibody to HBeAg. Subjects were ranked into three categories by alcohol consumption: nondrinkers, light drinkers (1-59 g/day), and heavy drinkers (greater than or equal to 60 g/day). The prevalence of liver abnormalities in HBsAg carriers increased with alcohol consumption. The prevalence differed significantly between nondrinkers and light drinkers in HBsAg carriers (p less than 0.001), but not in HBsAg-negative inhabitants. Prevalence also differed significantly between nondrinkers and heavy drinkers irrespective of HBsAg positivity (p less than 0.001). The highest prevalence of liver abnormalities was observed in HBeAg-positive heavy drinkers (53.8%). In conclusion, this study confirms that alcohol consumption intensifies the development of liver disease caused by hepatitis B virus. Therefore, the authors see a need to educate HBsAg carriers about the risks of consuming alcohol.
1982年至1985年期间，对日本冲绳八重山地区20岁以上的932名乙肝表面抗原（HBsAg）携带者和1704名HBsAg阴性居民进行了调查，以阐明习惯性饮酒与乙肝病毒感染之间的相互作用是否会引发肝脏疾病。所有受试者均接受了肝脏生化功能检测，并被询问了习惯性饮酒情况。对HBsAg携带者检测了乙肝e抗原（HBeAg）和HBeAg抗体。根据饮酒量将受试者分为三类：不饮酒者、轻度饮酒者（每天1 - 59克）和重度饮酒者（每天大于或等于60克）。HBsAg携带者中肝脏异常的患病率随饮酒量增加而上升。在HBsAg携带者中，不饮酒者和轻度饮酒者的患病率差异显著（p < 0.001），但在HBsAg阴性居民中无此差异。无论HBsAg是否阳性，不饮酒者和重度饮酒者的患病率也存在显著差异（p < 0.001）。肝脏异常患病率最高的是HBeAg阳性的重度饮酒者（53.8%）。总之，本研究证实饮酒会加剧乙肝病毒所致肝脏疾病的发展。因此，作者认为有必要对HBsAg携带者进行饮酒风险教育。
