印刷电解质门控晶体管生物传感器中的微流控机遇。
Microfluidic opportunities in printed electrolyte-gated transistor biosensors.
作者信息
Dorfman Kevin D, Adrahtas Demetra Z, Thomas Mathew S, Frisbie C Daniel
机构信息
Department of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, 421 Washington Ave. SE, Minneapolis, Minnesota 55455, USA.
出版信息
Biomicrofluidics. 2020 Jan 27;14(1):011301. doi: 10.1063/1.5131365. eCollection 2020 Jan.
Abstract
Printed electrolyte-gated transistors (EGTs) are an emerging biosensor platform that leverage the facile fabrication engendered by printed electronics with the low voltage operation enabled by ion gel dielectrics. The resulting label-free, nonoptical sensors have high gain and provide sensing operations that can be challenging for conventional chemical field effect transistor architectures. After providing an overview of EGT device fabrication and operation, we highlight opportunities for microfluidic enhancement of EGT sensor performance via multiplexing, sample preconcentration, and improved transport to the sensor surface.
摘要
印刷电解质门控晶体管（EGT）是一种新兴的生物传感器平台，它利用了印刷电子技术带来的便捷制造工艺以及离子凝胶电介质实现的低电压操作。由此产生的无标记、非光学传感器具有高增益，并提供了一些传感操作，而这些操作对于传统化学场效应晶体管架构来说可能具有挑战性。在概述了EGT器件的制造和操作之后，我们重点介绍了通过多路复用、样品预浓缩以及改善向传感器表面的传输来对EGT传感器性能进行微流体增强的机会。
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