Sun Lei, Li Fang-Hui, Li Tao, Min Zhu, Yang Luo-Dan, Gao Hao-En, Wu Da-Shuai, Xie Tian
School of Sport Sciences, Nanjing Normal University, No. 1 Wenyuan Road Qixia District, Nanjing, 210046, People's Republic of China.
Laboratory of Laser Sports Medicine, South China Normal University, Guangzhou, China.
Pflugers Arch. 2020 Feb;472(2):245-258. doi: 10.1007/s00424-020-02351-y. Epub 2020 Jan 31.
High-intensity interval training (HIIT) is a time-efficient alternative to moderate-intensity continuous training (MICT) to improve metabolic health in older individuals. However, differences in adipose tissue metabolism between these two approaches are unclear. Here, we evaluated the effects of HIIT and MICT on metabolic phenotypes in aged rats. HIIT significantly decreased fat mass, increased percent lean mass, decreased fat-to-lean ratio, reduced serum high-sensitivity C-reactive protein, increased serum interleukin-10 levels, and decreased perirenal adipose tissue leptin compared with rats in the sedentary (SED) group. HIIT also increased pregnenolone, cortisol, and corticosterone in both adipose tissue and serum. Both exercise modalities enhanced hormone-sensitive lipase and adipose triglyceride lipase expression compared with the SED group and decreased palmitic acid, stearic acid, octadecadienoic acid, urea, 1-heptadecanol, and α-tocopherol. MICT was related to glycerolipid metabolism, whereas HIIT was related to steroid hormone biosynthesis. Overall, HIIT showed more favorable regulation of anti-inflammatory activity than MICT.
高强度间歇训练（HIIT）是一种时间高效的替代方案，可替代中等强度持续训练（MICT）来改善老年人的代谢健康。然而，这两种训练方式在脂肪组织代谢方面的差异尚不清楚。在此，我们评估了HIIT和MICT对老年大鼠代谢表型的影响。与久坐（SED）组大鼠相比，HIIT显著降低了脂肪量，增加了瘦体重百分比，降低了脂肪与瘦体重的比例，降低了血清高敏C反应蛋白，提高了血清白细胞介素-10水平，并降低了肾周脂肪组织中的瘦素。HIIT还增加了脂肪组织和血清中的孕烯醇酮、皮质醇和皮质酮。与SED组相比，两种运动方式均增强了激素敏感性脂肪酶和脂肪甘油三酯脂肪酶的表达，并降低了棕榈酸、硬脂酸、十八碳二烯酸、尿素、1-十七烷醇和α-生育酚。MICT与甘油脂质代谢有关，而HIIT与类固醇激素生物合成有关。总体而言，与MICT相比，HIIT对抗炎活性的调节更有利。
