鱿鱼墨多糖通过调节NADPH氧化酶和连接蛋白43保护人成纤维细胞免受氧化应激。

Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43.

作者信息

Chen Ying, Liu Huazhong, Huang Hao, Ma Yuetang, Wang Ruihua, Hu Yong, Zheng Xiufen, Chen Chunmei, Tang Hongfeng

机构信息

Department of Dermatology, Nanchong Central Hospital, the Second Clinical Medical College of North Sichuan Medical College, Nanchong, China.

Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, China.

出版信息

Front Pharmacol. 2020 Jan 17;10:1574. doi: 10.3389/fphar.2019.01574. eCollection 2019.

Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against HO-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectively reduce the fibroblast oxidative damage mediated by the up-regulation of NADPH oxidase and Connexin43. Concurrently, squid ink polysaccharides decrease the ROS induced up-regulation of MMP1 and MMP9 to decrease MMP-mediated skin aging. Therefore, we hypothesize that squid ink polysaccharides play an antioxidant role by inhibiting the expression of NADPH oxidase and connexin43. This provides a new target for the effective clinical prevention and treatment of oxidative skin damage.