Department of Analytical Chemistry, University of Granada, 18071 Granada, Spain.
Research and Development of Functional Food Centre (CIDAF), 18016 Granada, Spain.
Molecules. 2020 Jan 29;25(3):596. doi: 10.3390/molecules25030596.
Dietary phenolic compounds are considered as bioactive compounds that have effects in different chronic disorders related to oxidative stress, inflammation process, or aging. These compounds, coming from a wide range of natural sources, have shown a pleiotropic behavior on key proteins that act as regulators. In this sense, this review aims to compile information on the effect exerted by the phenolic compounds and their metabolites on the main metabolic pathways involved in energy metabolism, inflammatory response, aging and their relationship with the biological properties reported in high prevalence chronic diseases. Numerous in vitro and in vivo studies have demonstrated their pleiotropic molecular mechanisms of action and these findings raise the possibility that phenolic compounds have a wide variety of roles in different targets.
膳食酚类化合物被认为是具有生物活性的化合物，它们对与氧化应激、炎症过程或衰老有关的多种慢性疾病有影响。这些化合物来自广泛的天然来源，对作为调节剂的关键蛋白表现出多种作用。在这方面，本综述旨在收集有关酚类化合物及其代谢物对参与能量代谢、炎症反应、衰老的主要代谢途径的影响的信息，以及它们与高患病率慢性疾病中报道的生物学特性的关系。大量的体外和体内研究已经证明了它们的多效性分子作用机制，这些发现提出了酚类化合物在不同靶标中可能具有广泛作用的可能性。
