Nogueira Marcel, Otuyama Leonardo Jun, Rocha Priscilla Alves, Pinto Vanusa Barbosa
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2020 Jan 31;18:eRW4686. doi: 10.31744/einstein_journal/2020RW4686. eCollection 2020.
To investigate the impact of pharmaceutical care-based interventions on type 2 diabetes mellitus .
PubMed®, Cochrane and Web of Science data bases were searched for randomized controlled clinical trials. Studies evaluating pharmaceutical care-based interventions in type 2 diabetes mellitus published between 2012 and 2017 were included. Glycated hemoglobin was defined as the primary endpoint; blood pressure, triglycerides and cholesterol as secondary endpoints. The random effects model was used in meta-analysis.
Fifteen trials involving 2,325 participants were included. Meta-analysis revealed considerable heterogeneity (I2>97%; p<0.001), reduction in glycated hemoglobin (-1.07%; 95%CI: -1.32; -0.83; p<0.001), glucose (-29.91mg/dL; 95%CI: -43.2; -16.6; p<0.001), triglyceride (19.8mg/dL; 95%CI: -36.6; -3.04; p=0.021), systolic blood pressure (-4.65mmHg; 95%CI: -8.9; -0.4; p=0.032) levels, and increased HDL levels (4.43mg/dL; 95%CI: 0.16; 8.70; p=0.042).
Pharmaceutical care-based clincal and education interventions have significant impact on type 2 diabetes mellitus . The tools Summary of Diabetes Self-Care Activities and the Morisky Medication Adherence Scale may be useful to monitor patients.
探讨基于药学服务的干预措施对2型糖尿病的影响。
检索PubMed®、Cochrane和Web of Science数据库中的随机对照临床试验。纳入2012年至2017年发表的评估基于药学服务的干预措施对2型糖尿病影响的研究。糖化血红蛋白被定义为主要终点；血压、甘油三酯和胆固醇为次要终点。荟萃分析采用随机效应模型。
纳入15项试验，共2325名参与者。荟萃分析显示存在显著异质性（I2>97%；p<0.001），糖化血红蛋白降低（-1.07%；95%CI：-1.32；-0.83；p<0.001），血糖降低（-29.91mg/dL；95%CI：-43.2；-16.6；p<0.001），甘油三酯降低（19.8mg/dL；95%CI：-36.6；-3.04；p=0.021），收缩压降低（-4.65mmHg；95%CI：-8.9；-0.4；p=0.032），高密度脂蛋白水平升高（4.43mg/dL；95%CI：0.16；8.70；p=0.042）。
基于药学服务的临床和教育干预措施对2型糖尿病有显著影响。糖尿病自我护理活动总结工具和莫斯基药物依从性量表可能有助于监测患者。
