Sharifipour S, Davoodi Rad K
Department of Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
New Microbes New Infect. 2020 Jan 7;34:100641. doi: 10.1016/j.nmni.2019.100641. eCollection 2020 Mar.
Epstein-Barr virus (EBV) as a herpes virus can be associated with numerous infections and cancers. The virus is known to cause infectious mononucleosis. There is no accurate estimation of the seroprevalence of EBV in Tehran, so this study aimed to estimate the seroprevalence of EBV among children and adults in Tehran, Iran. This descriptive-analytical study was conducted from 2015 to 2019 in Tehran province. In this study, 1220 people were selected by cross-sectional sampling, and blood samples and demographic data were collected by questionnaire. An anti-EBV-VCA ELISA kit was used to determine the seroprevalence of IgG against viral capsid antigen (VCA) among children and adults. In this study, most of the participants were in the age range of 20-29 years (349 individuals). The results of the ELISA test showed that the highest number of positive cases were in people over 40 years (94.8%), 30-39 years (92.5%) and 20-29 years were (92.1%), respectively. On the other hand, the seroprevalence of EBV infection in boys and girls up to 3 years was about 50%, and in adults, up to 40 years, it was about 95% (p < 0.001). The results of this study showed that in Tehran, the seroprevalence of VCA-IgG varied from 70% in primary school children to more than 90% in adults up to 40 years, indicating a broad spread of the virus. The results also indicate that the seroprevalence of EBV is high among men and women in Tehran.
爱泼斯坦-巴尔病毒（EBV）作为一种疱疹病毒，可引发多种感染和癌症。已知该病毒会导致传染性单核细胞增多症。目前尚无对德黑兰市EBV血清阳性率的准确估计，因此本研究旨在估算伊朗德黑兰市儿童和成人中EBV的血清阳性率。这项描述性分析研究于2015年至2019年在德黑兰省开展。在本研究中，通过横断面抽样选取了1220人，并通过问卷调查收集血液样本和人口统计学数据。使用抗EBV-VCA ELISA试剂盒来测定儿童和成人中针对病毒衣壳抗原（VCA）的IgG血清阳性率。在本研究中，大多数参与者年龄在20 - 29岁之间（349人）。ELISA检测结果显示，阳性病例数最多的分别是40岁以上人群（94.8%）、30 - 39岁人群（92.5%）和20 - 29岁人群（92.1%）。另一方面，3岁以下男孩和女孩中EBV感染的血清阳性率约为50%，在40岁以下成人中约为95%（p < 0.001）。本研究结果表明，在德黑兰，VCA-IgG的血清阳性率从小学生中的70%到40岁以下成人中的90%以上不等，表明该病毒广泛传播。结果还表明，德黑兰市男性和女性中EBV的血清阳性率都很高。
