School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
Hubei Maternal and Child Health Hospital, Hubei, China.
Acta Ophthalmol. 2020 Sep;98(6):e709-e714. doi: 10.1111/aos.14372. Epub 2020 Feb 6.
To determine the relationships among retinal/choroidal thickness, retinal microvascular network and visual field in high myopia.
This cross-sectional study included a total of 62 subjects, comprising 31 eyes with high myopia and 31 eyes with emmetropia or low myopia. Optical coherence tomography was used to quantify the thickness of ganglion cell complex (GCC), inner nuclear layer and outer plexiform layer (INOPL), outer retinal layer (ORL) and choroid layer (ChL). Optical coherence tomography angiography was used to quantify the superficial vessel density (SVD) and deep vessel density (DVD). Retinal light sensitivity (RLS) was measured by microperimetry-1 (MP1). The inner ring (1-1.75 mm), the outer ring (1.75-2.5 mm) and the whole ring (1-2.5 mm) around the macula were analysed and compared between the two groups. Pearson correlation analysis was performed to analyse the relationship among them.
In the highly myopic group, the thinning of retinal/choroidal thickness and the decrease in retinal vessel density and RLS were found when compared to the emmetropia or low myopia (p < 0.05). Decreased RLS was correlated with decreased ORL thickness (r = -0.469, p = 0.008) and choroid thickness (r = 0.398, p = 0.030). There was no correlation between retinal microvascular network parameters and RLS (p > 0.05), but DVD showed a negative correlation with ORL (r = -0.474, p = 0.007).
Early visual field defects in highly myopic eyes may be influenced by the ORL loss and defect of choroidal circulation. The deep retinal microvascular network may have a compensatory action in the hypoxic setting of high myopia.
探讨高度近视患者视网膜/脉络膜厚度、视网膜微血管网络与视野之间的关系。
本横断面研究共纳入 62 例患者，包括 31 只高度近视眼、31 只正视眼或低度近视眼。采用光学相干断层扫描（OCT）定量测量神经节细胞复合体（GCC）、内丛状层（INL）和外界膜（OPL）、外视网膜层（ORL）和脉络膜层（ChL）的厚度，采用 OCT 血管造影定量测量浅层血管密度（SVD）和深层血管密度（DVD）。采用微视野计 1（MP1）测量视网膜光敏感度（RLS）。对黄斑区周围内圈（1-1.75mm）、中圈（1.75-2.5mm）和全圈（1-2.5mm）进行分析，并比较两组之间的差异。采用 Pearson 相关分析分析它们之间的关系。
与正视眼或低度近视眼相比，高度近视组患者的视网膜/脉络膜厚度变薄，视网膜血管密度和 RLS 降低（p<0.05）。RLS 降低与 ORL 厚度（r=-0.469，p=0.008）和脉络膜厚度（r=0.398，p=0.030）降低呈负相关。视网膜微血管网络参数与 RLS 之间无相关性（p>0.05），但 DVD 与 ORL 呈负相关（r=-0.474，p=0.007）。
高度近视患者早期视野缺损可能与 ORL 丢失和脉络膜循环障碍有关。在高度近视的缺氧环境下，深层视网膜微血管网络可能具有代偿作用。
