Mukherjee Sudip, Liang Lily, Veiseh Omid
Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX 77005, USA.
Pharmaceutics. 2020 Feb 11;12(2):147. doi: 10.3390/pharmaceutics12020147.
Magnetic nanomaterials belong to a class of highly-functionalizable tools for cancer therapy owing to their intrinsic magnetic properties and multifunctional design that provides a multimodal theranostics platform for cancer diagnosis, monitoring, and therapy. In this review article, we have provided an overview of the various applications of magnetic nanomaterials and recent advances in the development of these nanomaterials as cancer therapeutics. Moreover, the cancer targeting, potential toxicity, and degradability of these nanomaterials has been briefly addressed. Finally, the challenges for clinical translation and the future scope of magnetic nanoparticles in cancer therapy are discussed.
磁性纳米材料因其固有的磁性和多功能设计，属于一类用于癌症治疗的高度可功能化工具，这种设计为癌症诊断、监测和治疗提供了一个多模态诊疗平台。在这篇综述文章中，我们概述了磁性纳米材料的各种应用以及这些纳米材料作为癌症治疗剂开发的最新进展。此外，还简要讨论了这些纳米材料的癌症靶向性、潜在毒性和可降解性。最后，探讨了临床转化面临的挑战以及磁性纳米颗粒在癌症治疗中的未来发展前景。
