Gradinaru Teodora C, Mihai Mara, Beiu Cristina, Tebeica Tiberiu, Giurcaneanu Calin
Dermatology, Elias Emergency University Hospital, Bucharest, ROU.
Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Cureus. 2020 Jan 10;12(1):e6621. doi: 10.7759/cureus.6621.
Melanonychia represents a brown to black discoloration of the nail plate that may be induced by benign or malignant causes. Two main mechanisms are involved in the appearance of melanonychias, i.e., melanocytic activation and melanocytic hyperplasia. The distinction between the two can be made based on the medical history of the patient, the clinical picture, dermoscopy, and histopathological examination and is essential for the adequate management of the patient. We review the main causes of melanonychia, with emphasis on the clues to the diagnosis of subungual melanoma.
甲下黑素沉着表现为甲板出现棕色至黑色变色，可由良性或恶性原因引起。甲下黑素沉着的出现涉及两种主要机制，即黑素细胞激活和黑素细胞增生。可根据患者病史、临床表现、皮肤镜检查和组织病理学检查对两者进行区分，这对患者的恰当治疗至关重要。我们综述了甲下黑素沉着的主要病因，重点关注甲下黑色素瘤的诊断线索。
