Guan Shuaimeng, Li Jiankang, Zhang Kun, Li Jingan
School of Life Science, Zhengzhou University, Zhengzhou, 450000, People's Republic of China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450000, People's Republic of China.
Heart Fail Rev. 2021 Sep;26(5):1273-1285. doi: 10.1007/s10741-020-09934-y.
Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in repairing the microenvironment of cardiovascular tissues and vascular regeneration. They provide a new method for the treatment of cardiovascular tissue repair and space-time control for the release of various therapeutic drugs, including small-molecule drugs, growth factors, and stem cells. Herein, this article reviews the occurrence and current treatment of CVD, as well as the repair of cardiovascular injury by several environmental responsive hydrogels systems currently used, mainly focusing on the delivery of growth factors or the application of cell therapy to revascularization. In addition, we will also discuss the enormous potential and personal perspectives of environmentally responsive hydrogels in cardiovascular repair.
心血管疾病（CVDs）对人类健康构成严重威胁，其在全球范围内具有高致残率和高死亡率的特点，如心肌梗死（MI）、动脉粥样硬化和心力衰竭。尽管干细胞移植和生长因子疗法前景广阔，但其低存活率以及在损伤部位的流失是该疗法的主要障碍。最近，水凝胶支架材料的发展为解决这一问题提供了新途径，已显示出治疗心血管疾病的潜力。在这些支架材料中，环境响应性水凝胶在修复心血管组织微环境和血管再生方面具有巨大前景。它们为心血管组织修复治疗以及各种治疗药物（包括小分子药物、生长因子和干细胞）的时空控制释放提供了新方法。在此，本文综述了心血管疾病的发生及当前治疗方法，以及目前使用的几种环境响应性水凝胶系统对心血管损伤的修复作用，主要聚焦于生长因子的递送或细胞疗法在血管再生中的应用。此外，我们还将讨论环境响应性水凝胶在心血管修复中的巨大潜力和个人观点。
