OIE and National Reference Laboratory for KHVD, Institute of Infectology, Friedrich-Loeffler-Institut (FLI), Greifswald-Insel Riems, Germany.
Institute of Muscle Biology & Growth, Junior Research Group Fish Growth Physiology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.
J Appl Microbiol. 2020 Jul;129(1):98-103. doi: 10.1111/jam.14616. Epub 2020 Mar 8.
Over the last years, there has been an enormous increase in the knowledge on koi herpesvirus (KHV), koi herpesvirus disease (KHVD), pathogenesis and virus variants. Different KHV lineages have clearly been identified, possible genomic changes during replication in different cell cultures at different temperatures but also in several hosts have been identified, a persistent stage of infection has been specified and it has been shown that infection with KHV is not host specific at all, but KHVD is. Additionally, it has been shown that it is possible to combat KHVD by immunization with inactivated and attenuated live vaccines using different delivery systems but also to benefit from alternative treatments with e.g. exopolysaccharids obtained from Arthrospira platensis.
在过去的几年中，人们对锦鲤疱疹病毒（KHV）、锦鲤疱疹病毒病（KHVD）、发病机制和病毒变体的了解有了巨大的增长。不同的 KHV 谱系已经被明确识别，在不同温度下的不同细胞培养物中复制过程中的可能的基因组变化，以及在几种宿主中也已经被识别，感染的持续阶段已经被确定，并且已经表明，KHV 的感染根本不是宿主特异性的，但 KHVD 是。此外，已经表明，通过使用不同的递送系统，用灭活和减毒活疫苗对 KHV 进行免疫接种，以及例如从螺旋藻中获得的胞外多糖等替代疗法，来对抗 KHVD 是可能的。
