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分流输注研究:对患者预后的影响,包括健康经济学。

Shunt infusion studies: impact on patient outcome, including health economics.

机构信息

Department of Clinical Neurosciences, Division of Neurosurgery, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

Department of Neurosurgery, Ospedale S.M. Goretti, Latina, Italy.

出版信息

Acta Neurochir (Wien). 2020 May;162(5):1019-1031. doi: 10.1007/s00701-020-04212-0. Epub 2020 Feb 20.

Abstract

OBJECTIVES

The diagnosis of shunt malfunction is often not straightforward. We have explored, in symptomatic shunted patients with hydrocephalus or pseudotumour cerebri syndrome (PTCS), the accuracy of CSF infusion tests in differentiating a functioning shunt from one with possible problems, and the health economic consequences.

METHODS

Participants: hydrocephalus/PTCS patients with infusion tests performed from January 2013 until December 2015. We followed patients up after 6 and 12 months from the test to determine whether they had improved, had persisting symptoms or had required urgent revision. We calculated the total cost savings of revision versus infusion tests and standard protocol of revision and ICP monitoring versus infusion tests.

RESULTS

Three hundred sixty-five shunt infusion tests had been performed where a shunt prechamber/reservoir was present. For hydrocephalus patients, more than half of the tests (~ 55%, 155 out of 280) showed no shunt malfunction versus 125 with possible malfunction (ages 4 months to 90 years old). For PTCS patients aged 10 to 77 years old, 47 had possible problems and 38 no indication for shunt malfunction. Overall, > 290 unnecessary revisions were avoided over 3 years' time. Two hundred fifty-eight (> 85%) of those non-surgically managed, remained well, did not deteriorate and did not require surgery. No infections were associated with infusion studies. For Cambridge, the overall savings from avoiding revisions was £945,415 annually.

CONCLUSIONS

Our results provide evidence of the importance of shunt testing in vivo to confirm shunt malfunction. Avoiding unnecessary shunt revisions carries a strong health benefit for patients that also translates to a significant financial benefit for the National Health Service and potentially for other healthcare systems worldwide.

摘要

目的

分流故障的诊断并不总是直接的。我们在有分流管的症状性脑积水或假性脑瘤综合征(PTCS)患者中,探索了脑脊液输注试验在区分功能良好的分流器与可能有问题的分流器方面的准确性,以及其对健康经济的影响。

方法

研究对象:2013 年 1 月至 2015 年 12 月进行输注试验的脑积水/PTCS 患者。我们在试验后 6 个月和 12 个月对患者进行随访,以确定他们是否有改善、持续存在症状或需要紧急修订。我们计算了修订与输注试验的总成本节约,以及标准修订和 ICP 监测与输注试验的成本节约。

结果

共进行了 365 次分流器输注试验,其中有分流前房/储液器。对于脑积水患者,超过一半的试验(~55%,280 例中有 155 例)显示无分流器故障,而 125 例可能有故障(年龄 4 个月至 90 岁)。对于 10 至 77 岁的 PTCS 患者,47 例可能存在问题,38 例无分流器故障迹象。总的来说,在 3 年的时间里避免了超过 290 次不必要的修订。258 例(>85%)非手术治疗患者情况良好,没有恶化,也不需要手术。没有感染与输注研究有关。对于剑桥大学,避免修订的总体节省为每年 945,415 英镑。

结论

我们的研究结果提供了体内分流器测试对确认分流器故障的重要性的证据。避免不必要的分流器修订对患者具有重要的健康益处,这也为国民保健制度带来了显著的经济效益,并且可能为全球其他医疗保健系统带来效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebf/7156359/cc8fd85d04d6/701_2020_4212_Fig1_HTML.jpg

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