Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
Molecules. 2020 Feb 17;25(4):880. doi: 10.3390/molecules25040880.
The direct C-H functionalization reaction is one of the most efficient strategies by which to introduce new functional groups into small organic molecules. Over time, iron complexes have emerged as versatile catalysts for carbine-transfer reactions with diazoalkanes under mild and sustainable reaction conditions. In this review, we discuss the advances that have been made using iron catalysts to perform C-H functionalization reactions with diazoalkanes. We give an overview of early examples employing stoichiometric iron carbene complexes and continue with recent advances in the C-H functionalization of C(sp)-H and C(sp)-H bonds, concluding with the latest developments in enzymatic C-H functionalization reactions using iron-heme-containing enzymes.
直接 C-H 功能化反应是将新官能团引入小分子有机化合物的最有效策略之一。随着时间的推移，铁配合物已成为在温和可持续的反应条件下通过重氮烷烃进行卡宾转移反应的多功能催化剂。在这篇综述中，我们讨论了使用铁催化剂进行重氮烷烃的 C-H 功能化反应的最新进展。我们首先概述了使用化学计量铁卡宾配合物的早期实例，然后介绍了 C(sp)-H 和 C(sp)-H 键的 C-H 功能化的最新进展，最后介绍了使用含铁血红素酶的酶促 C-H 功能化反应的最新进展。
