Department of Polymer Engineering and Technology, University of the Punjab, Lahore 54590, Pakistan; School of Biomedical Engineering and Health Sciences, Faculty of Engineering, University Teknologi Malaysia, 81300, Johor, Malaysia; School of Biomedical and Engineering, Shanghai Jiaotong University, Dongchuan Rd 800, 200240 Shanghai, China.
Department of Chemical Engineering, College of Engineering, King Saud University, P.O. BOX 800, Riyadh 11421, KSA, Saudi Arabia.
Int J Biol Macromol. 2020 May 15;151:584-594. doi: 10.1016/j.ijbiomac.2020.02.142. Epub 2020 Feb 17.
Arabinoxylan (AX) is a natural biological macromolecule with several potential biomedical applications. In this research, AX, nano-hydroxyapatite (n-HAp) and titanium dioxide (TiO) based polymeric nanocomposite scaffolds were fabricated by the freeze-drying method. The physicochemical characterizations of these polymeric nanocomposite scaffolds were performed for surface morphology, porosity, swelling, biodegradability, mechanical, and biological properties. The scaffolds exhibited good porosity and rough surface morphology, which were efficiently controlled by TiO concentrations. MC3T3-E1 cells were employed to conduct the biocompatibility of these scaffolds. Scaffolds showed unique biocompatibility in vitro and was favorable for cell attachment and growth. PNS3 proved more biocompatible, showed interconnected porosity and substantial mechanical strength compared to PNS1, PNS2 and PNS4. Furthermore, it has also showed more affinity to cells and cell growth. The results illustrated that the bioactive nanocomposite scaffold has the potential to find applications in the tissue engineering field.
阿拉伯木聚糖（AX）是一种具有多种潜在生物医学应用的天然生物大分子。在这项研究中，采用冷冻干燥法制备了以阿拉伯木聚糖（AX）、纳米羟基磷灰石（n-HAp）和二氧化钛（TiO）为基础的聚合物纳米复合材料支架。对这些聚合物纳米复合材料支架的物理化学特性进行了表面形貌、孔隙率、溶胀、生物降解性、机械性能和生物性能的研究。结果表明，支架具有良好的孔隙率和粗糙的表面形貌，这是通过 TiO 浓度的有效控制实现的。MC3T3-E1 细胞被用于研究这些支架的生物相容性。支架在体外表现出独特的生物相容性，有利于细胞附着和生长。与 PNS1、PNS2 和 PNS4 相比，PNS3 不仅具有更好的生物相容性、连通的孔隙率和更高的机械强度，而且对细胞和细胞生长也更具亲和力。结果表明，这种具有生物活性的纳米复合材料支架具有在组织工程领域应用的潜力。
