Khan Muhammad Umar Aslam, Razak Saiful Izwan Abd, Hassan Anwarul, Qureshi Saima, Stojanović Goran M
BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
Nanosciences and Nanotechnology Department, National Centre for Physics, Quaid-i-Azam University, Islamabad, Pakistan.
Front Bioeng Biotechnol. 2022 Apr 27;10:865059. doi: 10.3389/fbioe.2022.865059. eCollection 2022.
Wound healing is an important physiological process involving a series of cellular and molecular developments. A multifunctional hydrogel that prevents infection and promotes wound healing has great significance for wound healing applications in biomedical engineering. We have functionalized arabinoxylan and graphene oxide (GO) using the hydrothermal method, through cross-linking GO-arabinoxylan and polyvinyl alcohol (PVA) with tetraethyl orthosilicate (TEOS) to get multifunctional composite hydrogels. These composite hydrogels were characterized by FTIR, SEM, water contact angle, and mechanical testing to determine structural, morphological, wetting, and mechanical behavior, respectively. Swelling and biodegradation were also conducted in different media. The enhanced antibacterial activities were observed against different bacterial strains (, , and ); anticancer activities and biocompatibility assays were found effective against and cell lines due to the synergic effect of hydrogels. activities were conducted using a mouse full-thickness skin model, and accelerated wound healing was found without any major inflammation within 7 days with improved vascularization. From the results, these composite hydrogels might be potential wound dressing materials for biomedical applications.
伤口愈合是一个重要的生理过程，涉及一系列细胞和分子的发展。一种能够预防感染并促进伤口愈合的多功能水凝胶，对于生物医学工程中的伤口愈合应用具有重要意义。我们采用水热法对阿拉伯木聚糖和氧化石墨烯（GO）进行功能化处理，通过将GO-阿拉伯木聚糖与聚乙烯醇（PVA）用正硅酸四乙酯（TEOS）交联，得到多功能复合水凝胶。这些复合水凝胶通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、水接触角和力学测试进行表征，分别以确定其结构、形态、润湿性和力学行为。还在不同介质中进行了溶胀和生物降解实验。观察到该复合水凝胶对不同细菌菌株（、和）具有增强的抗菌活性；由于水凝胶的协同作用，抗癌活性和生物相容性检测对和细胞系有效。使用小鼠全层皮肤模型进行了活性实验，发现7天内伤口愈合加速，无任何严重炎症，血管生成得到改善。从结果来看，这些复合水凝胶可能是生物医学应用中潜在的伤口敷料材料。
