Driver-Dunckley Erika D, Zhang Nan, Shill Holly A, Mehta Shyamal H, Belden Christine M, Zamrini Edward Y, Davis Kathryn, Beach Thomas G, Adler Charles H
Drs. Driver-Dunckley, Mehta, and Adler are with the Department of Neurology of the Parkinson's Disease and Movement Disorders Center at the Mayo Clinic in Scottsdale, Arizona. Zhang is with the Section of Biostatistics at the Mayo Clinic in Scottsdale, Arizona. Shill is with the Barrow Neurological Institute in Phoenix, Arizona. Belden, Zamrini, Davis, and Beach are with the Banner Sun Health Research Institute in Sun City, Arizona.
Innov Clin Neurosci. 2019 Sep 1;16(9-10):27-29.
The Movement Disorder Society's Unified Parkinson's Disease Rating Scale (MDSUPDRS), Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Mayo Sleep Questionnaire, Epworth Sleepiness Scale, and Neuropsychiatric Inventory Questionnaire (NPI-Q) are validated instruments for assessing signs and symptoms of Parkinson's disease (PD). We sought to determine whether responses on the MDS-UPDRS correlate with responses to other scales used in patients with PD. Study subjects were enrolled in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Participants were selected if they had completed all scales within a one-month window. Spearman's rank correlation coefficients were calculated. A total of 96 eligible subjects were identified. High correlation (-values) was found between the SCOPA-AUT and MDS-UPDRS excessive saliva (0.73; <0.001), constipation (0.62; <0.001), and swallowing (0.59; <0.001) questions. The -values for the NPI-Q and MDS-UPDRS depression and anxiety questions were 0.53 (<0.001), and 0.67 (<0.001). MDS-UPDRS correlates well with some but not all questions from the SCOPA-AUT and NPI-Q. This work emphasizes the importance of employing multiple methods for assessing nonmotor symptoms in patients with PD.
运动障碍协会统一帕金森病评定量表（MDS-UPDRS）、帕金森病自主神经功能结局量表（SCOPA-AUT）、梅奥睡眠问卷、爱泼华嗜睡量表及神经精神问卷（NPI-Q）是用于评估帕金森病（PD）体征和症状的有效工具。我们试图确定MDS-UPDRS的回答是否与PD患者使用的其他量表的回答相关。研究对象纳入了亚利桑那州衰老与神经退行性疾病研究（AZSAND）。如果参与者在一个月内完成了所有量表，则被选中。计算了斯皮尔曼等级相关系数。共确定了96名符合条件的受试者。发现SCOPA-AUT与MDS-UPDRS的唾液过多（0.73；<0.001）、便秘（0.62；<0.001）及吞咽（0.59；<0.001）问题之间存在高度相关性（P值）。NPI-Q与MDS-UPDRS的抑郁和焦虑问题的P值分别为0.53（<0.001）和0.67（<0.001）。MDS-UPDRS与SCOPA-AUT和NPI-Q的部分而非全部问题具有良好的相关性。这项工作强调了采用多种方法评估PD患者非运动症状的重要性。
