Department of Chemistry, University of Wisconsin, Oshkosh, WI, 54901, USA.
Curr Opin Chem Biol. 2020 Apr;55:96-102. doi: 10.1016/j.cbpa.2020.01.003. Epub 2020 Feb 18.
Manganese (Mn) plays a complex role in the survival of pathogenic and symbiotic bacteria in eukaryotic hosts and is also important for free-living bacteria to thrive in stressful environments. This review summarizes new aspects of regulatory strategies to control intracellular Mn levels and gives an overview of several newly identified families of bacterial Mn transporters. Recent illustrative examples of advances in quantification of intracellular Mn pools and characterization of the effects of Mn perturbations are highlighted. These discoveries help define mechanisms of Mn selectivity and toxicity and could enable new strategies to combat pathogenic bacteria and promote growth of desirable bacteria.
锰（Mn）在真核宿主中对病原和共生细菌的生存起着复杂的作用，对自由生活的细菌在压力环境中茁壮成长也很重要。这篇综述总结了控制细胞内 Mn 水平的新的调控策略，并概述了几种新发现的细菌 Mn 转运体家族。本文还重点介绍了细胞内 Mn 池定量和 Mn 扰动特征方面的最新进展。这些发现有助于确定 Mn 选择性和毒性的机制，并可能为对抗病原菌和促进有益细菌的生长提供新的策略。
