College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China.
Int J Biol Macromol. 2020 Jun 15;153:373-384. doi: 10.1016/j.ijbiomac.2020.02.203. Epub 2020 Feb 19.
Ionizing radiation is increasingly used to successfully diagnose many human health problems, but ionizing radiation may cause damage to organs/tissues in the living organisms such as the spleen, liver, skin, and brain. Many radiation protective agents have been discovered, with the deepening of radiation research. Unfortunately, these protective agents have many side effects, which cause drug resistance, nausea, vomiting, osteoporosis, etc. The polysaccharides extracted from natural sources are widely available and low in toxicity. In vivo and in vitro experiments have demonstrated that polysaccharides have anti-radiation activity through anti-oxidation, immune regulation, protection of hematopoietic system and protection against DNA damage. Recently, some studies have shown that polysaccharides were resistant to radiation. In the review, the anti-radiation activities of polysaccharides from different sources are summarized, and the anti-radiation mechanisms are discussed as well. It can be used to develop more effective anti-radiation management drugs.
电离辐射越来越多地被用于成功诊断许多人类健康问题，但电离辐射可能会对生物体中的器官/组织造成损害，如脾脏、肝脏、皮肤和大脑。随着辐射研究的深入，已经发现了许多辐射防护剂。不幸的是，这些防护剂有许多副作用，如耐药性、恶心、呕吐、骨质疏松症等。从天然来源提取的多糖广泛存在且毒性低。体内和体外实验表明，多糖通过抗氧化、免疫调节、保护造血系统和防止 DNA 损伤来具有抗辐射活性。最近的一些研究表明，多糖具有抗辐射性。在综述中，总结了不同来源多糖的抗辐射活性，并讨论了其抗辐射机制。它可以用于开发更有效的抗辐射管理药物。
