Wheldone: Characterization of a Unique Scaffold from the Coculture of and .

Wheldone () was isolated and elucidated from a coculture of (NRRL 181) and (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate , whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound displayed cytotoxic activity against breast, ovarian, and melanoma cancer cell lines.