Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China.
Int J Environ Res Public Health. 2020 Feb 21;17(4):1395. doi: 10.3390/ijerph17041395.
Antimicrobial resistance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public health, clinical and economic outcomes due to emergence of these AMRs are rarely studied and reported. This review was aimed to summarize the findings from published studies to report the outcome impacts due to AMR of malaria, tuberculosis and HIV and briefly discuss the implications for application to other infectious diseases. PubMed/Medline and Google Scholar databases were used for search of empirical and peer-reviewed papers reporting public health, clinical and economic outcomes due to AMR of malaria, tuberculosis and HIV. Papers published through 1 December 2019 were included in this review. A total of 76 studies were included for this review, including 16, 49 and 11 on public health, clinical and economic outcomes, respectively. The synthesized data indicated that the emergence and spread of AMR of malaria, tuberculosis and HIV have resulted in adverse public health, clinical and economic outcomes. AMR of malaria, tuberculosis and HIV results in significant adverse impacts on public health, clinical and economic outcomes. Evidence from this review suggests the needs to consider the similar studies for other infectious diseases.
抗微生物药物耐药性（AMR）不仅对公共卫生产生影响，而且对临床和经济结果也构成了全球性威胁。在过去的几十年中，已经有许多研究专注于传染病中 AMR 的监测、机制和诊断，但是由于这些 AMR 的出现对公共卫生、临床和经济结果的影响很少得到研究和报告。本综述旨在总结已发表研究的结果，报告疟疾、结核病和艾滋病毒的 AMR 对公共卫生、临床和经济结果的影响，并简要讨论将其应用于其他传染病的意义。使用 PubMed/Medline 和 Google Scholar 数据库搜索报告疟疾、结核病和艾滋病毒的 AMR 对公共卫生、临床和经济结果影响的经验和同行评议论文。本综述纳入了截至 2019 年 12 月 1 日发表的论文。本综述共纳入了 76 项研究，分别有 16、49 和 11 项研究涉及公共卫生、临床和经济结果。综合数据表明，疟疾、结核病和艾滋病毒的 AMR 的出现和传播导致了不良的公共卫生、临床和经济结果。疟疾、结核病和艾滋病毒的 AMR 对公共卫生、临床和经济结果产生重大不利影响。本综述中的证据表明，需要考虑针对其他传染病开展类似的研究。
