Joergensen Kristina M, Vestergaard Christian, Joergensen Morten S, Eiken Aleksander, Malmstedt-Miller Martin, Schultz Anders N Ø, Deleuran Mette, Zibert John R
LEO Innovation Lab, Copenhagen, Denmark.
Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Dermatol Res Pract. 2020 Feb 13;2020:8915893. doi: 10.1155/2020/8915893. eCollection 2020.
Atopic dermatitis (AD) is a chronic skin condition where nonadherence often results in lack of disease control.
We wanted to determine whether the combination of an electronic memory button and a supportive application (app) would affect the Quality of Life and subjective and objective severity measures among AD patients over one month following the patient's normal schedules of treatment.
A randomized, investigator-blinded, prospective observational feasibility study for one month where patients diagnosed with AD were randomized based on POEM severity score and divided into 3 groups. The 3 groups were (1) the control group with two consultations, (2) in addition to group 1, patients also received electronic memory buttons to click every time they used their topical products, and (3) in addition to group 2, patients also received an app to track their treatment schedules. At both consultations, patients were evaluated using SCORAD, EASI, POEM, and DLQI.
96 patients were enrolled and randomized, of which 83 patients completed the study. EASI and SCORAD scores were lower in all groups at 2 consultation ( < 0.05); however, these were highly significant for group 3 ( < 0.05); however, these were highly significant for group 3 ( < 0.05); however, these were highly significant for group 3 ( < 0.05); however, these were highly significant for group 3 (.
A reduction in severity following objective assessments of the AD was observed for all groups and was highly significant for patients offered a memory button and the corresponding app. Furthermore, patients reported a significant subjective beneficial effect if they used the memory button and app. This indicates that digital solutions may have a benefit in clinical practice and may reduce nonadherence and increase the wellbeing of the patients.
特应性皮炎（AD）是一种慢性皮肤病，治疗依从性差常导致疾病无法得到控制。
我们想确定电子记忆按钮和辅助应用程序（app）相结合，是否会在患者正常治疗方案的一个月时间里，对AD患者的生活质量以及主观和客观严重程度指标产生影响。
一项为期一个月的随机、研究者设盲的前瞻性观察可行性研究，根据POEM严重程度评分将诊断为AD的患者随机分组，分为3组。3组分别为：（1）进行两次咨询的对照组；（2）除第1组外，患者每次使用外用产品时还需点击电子记忆按钮；（3）除第2组外，患者还可使用一款app来跟踪治疗计划。在两次咨询时，使用SCORAD、EASI、POEM和DLQI对患者进行评估。
96名患者入组并随机分组，其中83名患者完成了研究。在两次咨询时，所有组的EASI和SCORAD评分均较低（<0.05）；然而，第3组的差异非常显著（<0.05）；然而，第3组的差异非常显著（<0.05）；然而，第3组的差异非常显著（<0.05）；然而，第3组的差异非常显著（<0.05）。
所有组在对AD进行客观评估后严重程度均有所降低，对于使用记忆按钮和相应app的患者，降低程度非常显著。此外，患者报告称，如果使用记忆按钮和app，会有显著的主观有益效果。这表明数字解决方案在临床实践中可能有益，可减少治疗不依从性并提高患者的健康水平。
