Danish Dementia Research Centre, Department of Neurology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Int J Geriatr Psychiatry. 2020 Jul;35(7):693-701. doi: 10.1002/gps.5286. Epub 2020 Mar 9.
Brief Assessment of Impaired Cognition (BASIC), which combines self- and informant report with cognitive testing, was previously found to be highly accurate in identification of dementia and cognitive impairment. The aim of the present study was to develop and validate a questionnaire version of BASIC, the BASIC-Q, for use in community settings.
In order to construct a questionnaire version of BASIC, we substituted cognitive testing with questions regarding orientation. BASIC-Q was validated based on further analysis of data from the primary BASIC validation study, where patients consecutively referred from general practice were tested at their first memory clinic admission prior to diagnosis. Control participants were primarily recruited among participating patients' relatives. Expert clinical diagnosis was subsequently used as reference standard for estimation of classification accuracy.
A high discriminative validity (sensitivity 0.92, specificity 0.97) for cognitive impairment (n = 159) vs socio-demographically matched control participants (n = 109) was found. In comparison, the MMSE had 0.76 sensitivity and 0.81 specificity. Administration time for BASIC-Q was less than 5 minutes compared to approximately 10 minutes for the MMSE.
BASIC-Q is a brief, efficient and valid tool for identification of cognitive impairment in a clinical setting. Further validation in a community setting is needed.
简要认知评估（BASIC）结合了自我报告和知情者报告以及认知测试，先前已被证实可高度准确地识别痴呆和认知障碍。本研究的目的是开发和验证 BASIC 的问卷版本，即 BASIC-Q，以便在社区环境中使用。
为了构建 BASIC 的问卷版本，我们用有关定向的问题替代了认知测试。BASIC-Q 的验证是基于对主要 BASIC 验证研究数据的进一步分析，在该研究中，患者在首次记忆诊所就诊时被连续从普通诊所转诊，以便在诊断前进行测试。对照组主要从参与的患者的亲属中招募。随后，使用专家临床诊断作为参考标准来评估分类准确性。
对于认知障碍（n = 159）与社会人口统计学匹配的对照组参与者（n = 109），BASIC-Q 具有较高的判别有效性（敏感性 0.92，特异性 0.97）。相比之下，MMSE 的敏感性为 0.76，特异性为 0.81。BASIC-Q 的管理时间不到 5 分钟，而 MMSE 则需要大约 10 分钟。
BASIC-Q 是一种在临床环境中识别认知障碍的简短、高效和有效的工具。需要在社区环境中进一步验证。
