Antimalarial Activity of Leaf Extracts in -Infected Mice.

OBJECTIVE

To evaluate the antimalarial effect of aqueous methanolic extract and solvent fractions of leaves against in mice model.

METHOD

leaves were extracted with 80% methanol and dried. The dried crude extract was then defatted and further fractionated with chloroform, ethyl acetate, and butanol. Acute oral toxicity test was performed as per the Organization for Economic Cooperation and Development guideline 425. Peter's 4-day suppressive test was used to determine the antimalarial activity of the extract and fractions.

RESULT

The crude leaf extract of leaves against < 0.001) chemosuppression compared to the negative control. Both the extract and fractions were able to prevent induced body weight loss and body temperature reduction and also increased the survival time of the mice as compared to the negative control. The aqueous methanolic leaf extract of leaves were extracted with 80% methanol and dried. The dried crude extract was then defatted and further fractionated with chloroform, ethyl acetate, and butanol. Acute oral toxicity test was performed as per the Organization for Economic Cooperation and Development guideline 425. Peter's 4-day suppressive test was used to determine the.

CONCLUSION

The extracts of leaves showed promising antimalarial activity, with no sign of toxicity and therefore may support its traditional use for the treatment of malaria. leaves were extracted with 80% methanol and dried. The dried crude extract was then defatted and further fractionated with chloroform, ethyl acetate, and butanol. Acute oral toxicity test was performed as per the Organization for Economic Cooperation and Development guideline 425. Peter's 4-day suppressive test was used to determine the.