Department of Nanoengineering, Materials Science and Engineering Program, University of California, San Diego, CA, USA.
Department of Ophthalmology, Stanford University, Stanford, CA, USA.
Methods Mol Biol. 2020;2126:141-153. doi: 10.1007/978-1-0716-0364-2_13.
Cell therapy is revolutionizing modern medicine. To promote this emerging therapy, the ability to image and track therapeutic cells is critical to monitor the progress of the treatment. Ultrasound imaging is promising in tracking therapeutic cells but suffers from poor contrast against local tissues. Therefore, it is critical to increase the ultrasound contrast of therapeutic cells over local tissue at the injection site. Here, we describe a method to increase the ultrasound intensity of therapeutic cells with nanoparticles to make the injected therapeutic cells more visible.
细胞治疗正在彻底改变现代医学。为了促进这种新兴疗法，对治疗细胞进行成像和跟踪的能力对于监测治疗进展至关重要。超声成像是跟踪治疗细胞的有前途的方法，但与局部组织的对比度差。因此，重要的是要增加治疗细胞相对于注射部位局部组织的超声强度。在这里，我们描述了一种使用纳米颗粒增加治疗细胞超声强度的方法，以使注入的治疗细胞更可见。
