Wang Peixia, Wang Tao, Hong Juanji, Yan Xiyun, Liang Minmin
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Experimental Center of Advanced Materials School of Materials Science & Engineering, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, China.
Front Bioeng Biotechnol. 2020 Feb 6;8:15. doi: 10.3389/fbioe.2020.00015. eCollection 2020.
Nanozymes are nanomaterials with intrinsic enzyme-like properties. They can specifically catalyze substrates of natural enzymes under physiological condition with similar catalytic mechanism and kinetics. Compared to natural enzymes, nanozymes exhibit the unique advantages including high catalytic activity, low cost, high stability, easy mass production, and tunable activity. In addition, as a new type of artificial enzymes, nanozymes not only have the enzyme-like catalytic activity, but also exhibit the unique physicochemical properties of nanomaterials, such as photothermal properties, superparamagnetism, and fluorescence, etc. By combining the unique physicochemical properties and enzyme-like catalytic activities, nanozymes have been widely developed for detection and disease monitoring and treatment. Here we mainly summarized the applications of nanozymes for disease imaging and detection to explore their potential application in disease diagnosis and precision medicine.
纳米酶是具有内在类酶特性的纳米材料。它们能够在生理条件下通过类似的催化机制和动力学特异性催化天然酶的底物。与天然酶相比，纳米酶具有高催化活性、低成本、高稳定性、易于大规模生产以及活性可调等独特优势。此外，作为一种新型人工酶，纳米酶不仅具有类酶催化活性，还展现出纳米材料独特的物理化学性质，如光热性质、超顺磁性和荧光等。通过结合独特的物理化学性质和类酶催化活性，纳米酶已被广泛开发用于疾病检测、监测和治疗。在此，我们主要总结了纳米酶在疾病成像和检测方面的应用，以探索它们在疾病诊断和精准医学中的潜在应用。
