Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain.
Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain.
Cells. 2020 Feb 28;9(3):575. doi: 10.3390/cells9030575.
Probiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of CECT5716 during pregnancy and lactation periods impacts maternal and offspring plasma lipid profile, immune system and microbiota. Rats were supplemented with the probiotic during gestation and two weeks of lactation. After supplementation, although the microbiota composition was not affected, the probiotic strain was detected in all cecal contents of dams and in some of their pups. Dams showed reduced proportion of T cytotoxic cells in the mesenteric lymph nodes, modulation of intestinal cytokines (IL-10 and IL-12) and changes in plasma fatty acids (20:0, 22:0, 20:5 , and 18:3 ). Pups showed changes in immunoglobulins (intestinal IgA and plasmatic IgG2a and IgG2c) and fatty acid profile (17:0, 22:0, and 18:2 ). Overall, CECT5716 supplementation contributed to beneficially modulating the immune system of the mother and its offspring.
益生菌在生命早期的应用显示出了潜力。本研究旨在探讨在妊娠和哺乳期给予 CECT5716 是否会影响母体和后代的血浆脂质谱、免疫系统和微生物群。在妊娠和哺乳期，大鼠补充了该益生菌。补充后，尽管微生物群组成没有受到影响，但该益生菌菌株在所有母体盲肠内容物和部分幼崽中均被检测到。母鼠肠系膜淋巴结中的 T 细胞毒性细胞比例降低，肠道细胞因子（IL-10 和 IL-12）发生变化，血浆脂肪酸（20:0、22:0、20:5 和 18:3）也发生了变化。幼崽的免疫球蛋白（肠道 IgA 以及血浆 IgG2a 和 IgG2c）和脂肪酸谱（17:0、22:0 和 18:2）也发生了变化。总的来说，CECT5716 的补充有助于有益地调节母体及其后代的免疫系统。
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