Garcia Isadora Martini, Rodrigues Stéfani Becker, Rodrigues Gama Maria Eduarda, Branco Leitune Vicente Castelo, Melo Mary Anne, Collares Fabrício Mezzomo
Dental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil.
Ph.D. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD, 21201, USA.
Bioact Mater. 2020 Feb 21;5(2):228-232. doi: 10.1016/j.bioactmat.2020.02.007. eCollection 2020 Jun.
To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, . The solutions formulated with concentrations ranging from 0.125 to 0.50 wt% enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens. After 10 min-contact, the solution at lower concentration has reached total fungal elimination. The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration. The PHMGH aqueous solutions at 0.125 wt% could be applied to promote interim denture liner disinfection without promoting the loss of materials' mechanical property.
为减轻义齿性口炎和口腔念珠菌病的负担，研究了一种含有聚六亚甲基胍盐酸盐（PHMGH）的水溶液作为抗真菌消毒剂，用于对抗导致这些口腔疾病的主要病因。配制浓度范围为0.125至0.50 wt%的溶液，在与义齿衬垫标本上形成的72小时成熟念珠菌生物膜初始接触5分钟时，能增强消毒效果。接触10分钟后，较低浓度的溶液已实现完全真菌清除。结果还表明，义齿衬垫在与最高测试浓度的溶液最长接触时间后，仍保留其机械性能。0.125 wt%的PHMGH水溶液可用于促进临时义齿衬垫消毒，同时不会导致材料机械性能损失。
