溃疡性结肠炎发育异常的内镜监测策略
Endoscopic surveillance strategies for dysplasia in ulcerative colitis.
作者信息
Verdon Christine, Aruljothy Achuthan, Lakatos Peter L, Bessissow Talat
机构信息
Gastroenterology, McGill University Health Centre, Montreal, Québec, Canada.
1st Department of Medicine, Semmelweis University, Budapest, Hungary.
出版信息
Frontline Gastroenterol. 2019 Apr 12;11(2):124-132. doi: 10.1136/flgastro-2018-101056. eCollection 2020 Mar.
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with an increased risk of colorectal cancer (CRC). This has led to the implementation of surveillance programmes to minimise this risk. Overall, these proactive programmes in association with better medical therapies have reduced the incidence of CRC in this population. Specific populations remain at increased risk, such as younger age at diagnosis, primary sclerosing cholangitis, colonic strictures and pseudopolyps. The majority of gastrointestinal international societies favour chromoendoscopy with targeted biopsies or random biopsies. The aim of this review is to present the current literature on dysplasia surveillance, the methodology and endoscopic technology available to assess dysplasia in UC.
摘要
溃疡性结肠炎（UC）是一种慢性炎症性肠病，患结直肠癌（CRC）的风险增加。这导致了实施监测计划以将这种风险降至最低。总体而言，这些积极主动的计划与更好的药物治疗相结合，降低了该人群中结直肠癌的发病率。特定人群的风险仍然较高，例如诊断时年龄较小、原发性硬化性胆管炎、结肠狭窄和假息肉。大多数胃肠国际学会倾向于采用靶向活检或随机活检的色素内镜检查。本综述的目的是介绍有关发育异常监测的当前文献、评估UC中发育异常的可用方法和内镜技术。
相似文献
1
Endoscopic surveillance strategies for dysplasia in ulcerative colitis.溃疡性结肠炎发育异常的内镜监测策略
Frontline Gastroenterol. 2019 Apr 12;11(2):124-132. doi: 10.1136/flgastro-2018-101056. eCollection 2020 Mar.
2
Random biopsies during surveillance colonoscopy increase dysplasia detection in patients with primary sclerosing cholangitis and ulcerative colitis.在监测性结肠镜检查期间进行随机活检会增加原发性硬化性胆管炎和溃疡性结肠炎患者的异型增生检出率。
J Crohns Colitis. 2013 Dec;7(12):974-81. doi: 10.1016/j.crohns.2013.02.009. Epub 2013 Mar 20.
3
Role of random biopsies in surveillance of dysplasia in ulcerative colitis patients with high risk of colorectal cancer.随机活检在结直肠癌高风险溃疡性结肠炎患者发育异常监测中的作用
Intest Res. 2016 Jul;14(3):264-9. doi: 10.5217/ir.2016.14.3.264. Epub 2016 Jun 27.
4
Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis?溃疡性结肠炎患者的发育异常和结肠直肠癌在内镜检查中可见吗？
Gastrointest Endosc. 2007 Jun;65(7):998-1004. doi: 10.1016/j.gie.2006.09.025. Epub 2007 Apr 23.
5
High Adherence to Surveillance Guidelines in Inflammatory Bowel Disease Patients Results in Low Colorectal Cancer and Dysplasia Rates, While Rates of Dysplasia are Low Before the Suggested Onset of Surveillance.炎症性肠病患者高度遵循监测指南可降低结直肠癌和异型增生发生率，而在建议开始监测之前异型增生发生率较低。
J Crohns Colitis. 2019 Sep 27;13(10):1343-1350. doi: 10.1093/ecco-jcc/jjz066.
6
Colorectal polyps in ulcerative colitis and Crohn's colitis.溃疡性结肠炎和克罗恩氏结肠炎中的大肠息肉。
Minerva Gastroenterol Dietol. 2015 Dec;61(4):215-22. Epub 2015 Oct 7.
7
Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial.染色内镜与自发荧光成像在长期溃疡性结肠炎患者肿瘤检测中的比较（FIND-UC）：一项国际、多中心、随机对照试验。
Lancet Gastroenterol Hepatol. 2018 May;3(5):305-316. doi: 10.1016/S2468-1253(18)30055-4. Epub 2018 Mar 20.
8
Incidence, Risk Factors, and Outcomes of Colorectal Cancer in Patients With Ulcerative Colitis With Low-Grade Dysplasia: A Systematic Review and Meta-analysis.低度发育异常的溃疡性结肠炎患者结直肠癌的发病率、危险因素及预后：一项系统评价和荟萃分析
Clin Gastroenterol Hepatol. 2017 May;15(5):665-674.e5. doi: 10.1016/j.cgh.2016.11.025. Epub 2016 Dec 1.
9
Cost-effectiveness analysis of chromoendoscopy for colorectal cancer surveillance in patients with ulcerative colitis.结肠镜下染色对溃疡性结肠炎患者结直肠癌监测的成本效果分析。
Gastrointest Endosc. 2014 Mar;79(3):455-65. doi: 10.1016/j.gie.2013.10.026. Epub 2013 Nov 18.
10
Advances in the Diagnosis and Management of Colonic Dysplasia in Patients With Inflammatory Bowel Disease.炎症性肠病患者结肠发育异常的诊断与管理进展
Gastroenterol Hepatol (N Y). 2017 Jun;13(6):357-362.
引用本文的文献
1
The Importance of Post-Inflammatory Polyps (PIPs) in Colorectal Cancer Surveillance in Inflammatory Bowel Diseases.炎症后息肉（PIPs）在炎症性肠病结直肠癌监测中的重要性
J Clin Med. 2025 Jan 8;14(2):333. doi: 10.3390/jcm14020333.
2
A case of appendix adenocarcinoma associated with ulcerative colitis.一例阑尾腺癌合并溃疡性结肠炎
Clin Case Rep. 2021 Aug 30;9(9):e04768. doi: 10.1002/ccr3.4768. eCollection 2021 Sep.
3
Dysplasia Surveillance in Inflammatory Bowel Disease: A Cohort Study.炎症性肠病的发育异常监测：一项队列研究。
GE Port J Gastroenterol. 2021 Feb;28(2):97-105. doi: 10.1159/000510728. Epub 2020 Oct 19.
本文引用的文献
1
High Adherence to Surveillance Guidelines in Inflammatory Bowel Disease Patients Results in Low Colorectal Cancer and Dysplasia Rates, While Rates of Dysplasia are Low Before the Suggested Onset of Surveillance.炎症性肠病患者高度遵循监测指南可降低结直肠癌和异型增生发生率，而在建议开始监测之前异型增生发生率较低。
J Crohns Colitis. 2019 Sep 27;13(10):1343-1350. doi: 10.1093/ecco-jcc/jjz066.
2
Comparison of Endoscopic Dysplasia Detection Techniques in Patients With Ulcerative Colitis: A Systematic Review and Network Meta-analysis.比较溃疡性结肠炎患者内镜下黏膜病变检测技术：系统评价和网络荟萃分析。
Inflamm Bowel Dis. 2018 Nov 29;24(12):2518-2526. doi: 10.1093/ibd/izy188.
3
Chromoendoscopy for Dysplasia Surveillance in Inflammatory Bowel Disease.染色内镜在炎症性肠病异型增生监测中的应用。
Inflamm Bowel Dis. 2018 Jun 8;24(7):1440-1452. doi: 10.1093/ibd/izy043.
4
Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial.染色内镜与自发荧光成像在长期溃疡性结肠炎患者肿瘤检测中的比较（FIND-UC）：一项国际、多中心、随机对照试验。
Lancet Gastroenterol Hepatol. 2018 May;3(5):305-316. doi: 10.1016/S2468-1253(18)30055-4. Epub 2018 Mar 20.
5
A Randomized Trial Comparing High Definition Colonoscopy Alone With High Definition Dye Spraying and Electronic Virtual Chromoendoscopy for Detection of Colonic Neoplastic Lesions During IBD Surveillance Colonoscopy.一项比较单独使用高清结肠镜检查与高清染色喷洒和电子虚拟染色内镜检查在 IBD 监测结肠镜检查中对结直肠肿瘤性病变检测的随机试验。
Am J Gastroenterol. 2018 Feb;113(2):225-234. doi: 10.1038/ajg.2017.417. Epub 2017 Nov 14.
6
Endoscopy in inflammatory bowel disease: advances in dysplasia detection and management.炎症性肠病中的内镜检查：发育异常检测与管理的进展
Gastrointest Endosc. 2017 Dec;86(6):962-971. doi: 10.1016/j.gie.2017.09.030. Epub 2017 Oct 4.
7
Chromoendoscopy, Narrow-Band Imaging or White Light Endoscopy for Neoplasia Detection in Inflammatory Bowel Diseases.用于炎症性肠病肿瘤检测的色素内镜检查、窄带成像或白光内镜检查。
Dig Dis Sci. 2017 Nov;62(11):2982-2990. doi: 10.1007/s10620-017-4772-y. Epub 2017 Sep 30.
8
Strategies for detecting colon cancer in patients with inflammatory bowel disease.炎症性肠病患者结肠癌的检测策略。
Cochrane Database Syst Rev. 2017 Sep 18;9(9):CD000279. doi: 10.1002/14651858.CD000279.pub4.
9
Impact of mucosal inflammation on risk of colorectal neoplasia in patients with ulcerative colitis: a systematic review and meta-analysis.黏膜炎症对溃疡性结肠炎患者结直肠肿瘤风险的影响：系统评价和荟萃分析。
Gastrointest Endosc. 2017 Dec;86(6):1006-1011.e8. doi: 10.1016/j.gie.2017.07.028. Epub 2017 Jul 24.
10
Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial.染色内镜与窄带成像在 UC 中的对比：一项前瞻性随机对照试验。
Gut. 2018 Jun;67(6):1087-1094. doi: 10.1136/gutjnl-2016-313213. Epub 2017 Jul 11.
Zotero 插件