Nogueira T O, Zorn T M, Stene T, Koppang H S
Department of Pathology, Dental Faculty of São José dos Campos, UNESP, São Paulo, Brazil.
Acta Anat (Basel). 1988;133(1):45-9. doi: 10.1159/000146613.
Twelve female Wistar rats received 1.5 mg/kg of colchicine (CLC) intravenously. Control animals were similarly injected with isotonic saline solution. The animals were killed 5 h, 24 h, 3 days and 7 days after injection. Ninety minutes prior to sacrifice, all animals received an intraperitoneal injection of 3H-proline. Autoradiograms of maxillary incisors showed that CLC increased the retention of the labeled precursor in the odontoblasts. It was also shown that the odontoblasts in the different sectors of the rat incisor present different sensitivities to the CLC action.
12只雌性Wistar大鼠静脉注射1.5毫克/千克秋水仙碱（CLC）。对照动物同样注射等渗盐溶液。在注射后5小时、24小时、3天和7天处死动物。在处死前90分钟，所有动物腹腔注射3H-脯氨酸。上颌切牙的放射自显影片显示，CLC增加了成牙本质细胞中标记前体的保留。还表明，大鼠切牙不同区域的成牙本质细胞对CLC作用呈现不同的敏感性。
