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尼日利亚包奇州 Gamawa 地方政府区产前诊所就诊者中乙型肝炎病毒的血清流行率。

Seroprevalence of hepatitis B virus among antenatal clinic attendees in Gamawa Local Government Area, Bauchi State, Nigeria.

机构信息

Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.

Department of Community Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.

出版信息

BMC Infect Dis. 2020 Mar 6;20(1):194. doi: 10.1186/s12879-020-4863-9.

Abstract

BACKGROUND

Hepatitis B virus disease is a potentially life-threatening liver infection and a major global health problem. It causes chronic infection and puts people at high risk of death from cirrhosis and liver cancer. WHO estimated 257 million people are living with hepatitis B virus (HBV) infection and in 2015 alone HBV resulted in to 887,000 deaths globally. We determined the prevalence and associated factors of hepatitis B virus infection among Antenatal Care (ANC) attendees in Gamawa Local Government Area, Bauchi State.

METHODS

We conducted a descriptive cross-sectional, health facility-based study between March and April 2018. We used systematic random sampling technique to recruit 210 pregnant women aged 15-49 years. With a structured questionnaire, we interviewed the respondents and collected blood sample to test for hepatitis B surface antigen. We calculated frequencies, means, proportions, and tested for associations using Epi Info 7.2 and Microsoft Excel.

RESULTS

The mean age of respondents was 24.5 ± 6.0 years; 112 (53%) of whom were younger than 25 years. All were married, 183 (87%) had no formal education and up to 190 (90%) were employed. Overall, 14 (6.7%) tested positive for HBsAg; women aged ≥35 years had the highest prevalence (10%). None with tertiary education tested positive and women married before 18 years had 13 (6.2%) prevalence.

CONCLUSIONS

The prevalence of HBsAg among pregnant women in Gamawa LGA was 6.7% which is quite lower than the national prevalence reported. We recommended improved surveillance of HBV infection and screening of women attending ANC.

摘要

背景

乙型肝炎病毒疾病是一种潜在的危及生命的肝脏感染,也是一个重大的全球健康问题。它导致慢性感染,使人们面临肝硬化和肝癌死亡的高风险。世界卫生组织估计,有 2.57 亿人感染乙型肝炎病毒(HBV),仅 2015 年一年,全球就有 88.7 万人死于乙型肝炎病毒。我们确定了包奇州 Gamawa 地方政府区产前护理(ANC)就诊者中乙型肝炎病毒感染的流行率和相关因素。

方法

我们于 2018 年 3 月至 4 月进行了一项描述性横断面、基于卫生机构的研究。我们使用系统随机抽样技术招募了 210 名年龄在 15-49 岁的孕妇。我们使用结构化问卷对受访者进行访谈,并采集血样检测乙型肝炎表面抗原。我们使用 Epi Info 7.2 和 Microsoft Excel 计算频率、平均值、比例,并进行关联检验。

结果

受访者的平均年龄为 24.5±6.0 岁;其中 112 人(53%)年龄小于 25 岁。所有人都已婚,183 人(87%)没有接受过正规教育,多达 190 人(90%)有工作。总的来说,有 14 人(6.7%)乙型肝炎表面抗原检测呈阳性;年龄≥35 岁的女性患病率最高(10%)。没有接受过高等教育的人检测呈阳性,18 岁前结婚的女性患病率为 6.2%(13 人)。

结论

Gamawa LGA 孕妇的 HBsAg 流行率为 6.7%,远低于全国报告的流行率。我们建议加强对乙型肝炎病毒感染的监测和对 ANC 就诊妇女的筛查。

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