老年人认知功能和姿势控制的共享神经基础。
Shared neural substrates of cognitive function and postural control in older adults.
机构信息
Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Epidemiology, Graduate School, of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Alzheimers Dement. 2020 Apr;16(4):621-629. doi: 10.1002/alz.12053. Epub 2020 Mar 8.
INTRODUCTION
Poor cognitive function and postural control co-occur in older adults. It is unclear whether they share neural substrates.
METHODS
Postural sway error during a novel visual tracking (VT) condition and gray matter volume (GMV) were compared between participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia (n = 179, mean age 82, 56% females, 56% white). Associations between VT error, cognitive function, and GMV were examined.
RESULTS
Greater VT error was associated with having dementia compared to NC or MCI (odds ratio [95% CI] = 2.15 [1.38, 3.36] and 1.58 [1.05, 2.38]). Regions with lower GMV related to greater VT error and worse cognition were: bilateral hippocampi, parahippocampi, entorhinal, and parietal cortices (all P ≤0.05). GMV of bilateral hippocampi and left parahippocampus explained >20% of VT error between dementia and NC.
DISCUSSION
Postural control during visuospatial tasks and dementia may share neural substrates, specifically memory-related regions.
简介
认知功能障碍和姿势控制在老年人中同时存在。目前尚不清楚它们是否具有共同的神经基础。
方法
比较认知功能正常（NC）、轻度认知障碍（MCI）或痴呆（n=179，平均年龄 82 岁，56%为女性，56%为白人）患者在新的视觉跟踪（VT）条件下的姿势摆动误差和灰质体积（GMV）。检查了 VT 误差、认知功能和 GMV 之间的相关性。
结果
与 NC 或 MCI 相比，VT 误差更大与痴呆有关（比值比[95%CI]为 2.15[1.38, 3.36]和 1.58[1.05, 2.38]）。与更大的 VT 误差和更差的认知相关的 GMV 较低的区域为：双侧海马体、海马旁回、内嗅皮质和顶叶皮质（均 P≤0.05）。双侧海马体和左海马旁回的 GMV 解释了痴呆和 NC 之间超过 20%的 VT 误差。
讨论
视觉空间任务期间的姿势控制和痴呆可能具有共同的神经基础，特别是与记忆相关的区域。
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