Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Epidemiology, Graduate School, of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alzheimers Dement. 2020 Apr;16(4):621-629. doi: 10.1002/alz.12053. Epub 2020 Mar 8.
Poor cognitive function and postural control co-occur in older adults. It is unclear whether they share neural substrates.
Postural sway error during a novel visual tracking (VT) condition and gray matter volume (GMV) were compared between participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia (n = 179, mean age 82, 56% females, 56% white). Associations between VT error, cognitive function, and GMV were examined.
Greater VT error was associated with having dementia compared to NC or MCI (odds ratio [95% CI] = 2.15 [1.38, 3.36] and 1.58 [1.05, 2.38]). Regions with lower GMV related to greater VT error and worse cognition were: bilateral hippocampi, parahippocampi, entorhinal, and parietal cortices (all P ≤0.05). GMV of bilateral hippocampi and left parahippocampus explained >20% of VT error between dementia and NC.
Postural control during visuospatial tasks and dementia may share neural substrates, specifically memory-related regions.
认知功能障碍和姿势控制在老年人中同时存在。目前尚不清楚它们是否具有共同的神经基础。
比较认知功能正常（NC）、轻度认知障碍（MCI）或痴呆（n=179，平均年龄 82 岁，56%为女性，56%为白人）患者在新的视觉跟踪（VT）条件下的姿势摆动误差和灰质体积（GMV）。检查了 VT 误差、认知功能和 GMV 之间的相关性。
与 NC 或 MCI 相比，VT 误差更大与痴呆有关（比值比[95%CI]为 2.15[1.38, 3.36]和 1.58[1.05, 2.38]）。与更大的 VT 误差和更差的认知相关的 GMV 较低的区域为：双侧海马体、海马旁回、内嗅皮质和顶叶皮质（均 P≤0.05）。双侧海马体和左海马旁回的 GMV 解释了痴呆和 NC 之间超过 20%的 VT 误差。
视觉空间任务期间的姿势控制和痴呆可能具有共同的神经基础，特别是与记忆相关的区域。
