Habte Getu, Nedi Teshome, Assefa Solomon
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Department of Pharmacy, College of Health Sciences, Mettu University, P.O. Box 318, Addis Ababa, Ethiopia.
J Trop Med. 2020 Feb 18;2020:9473250. doi: 10.1155/2020/9473250. eCollection 2020.
Malaria is among the leading causes of mortality and morbidity. Moreover, the emergence of resistance to antimalarial drugs is a major problem in controlling the disease. This makes the development of novel antimalarial drugs a necessity. Medicinal plants are important sources in discovering antimalarial drugs. is claimed for its antimalarial effect in Ethiopian folkloric medicine and endowed with antiplasmodial activity. In the present study, the antimalarial activity of the plant was investigated.
Acute toxicity was carried out using a standard procedure. To screen the antimalarial activity of the plant was investigated. against (ANKA), a 4-day suppressive test was employed. The extracts and fractions were given to infected mice by oral gavage at 100, 200, and 400 mg/kg/day for four consecutive days. Parameters such as parasitemia were then evaluated.
Any sign of toxicity was not observed in the oral acute toxicity test. The crude extracts and solvent fractions exerted a significant ( < 0.05) inhibition of parasite load compared to the negative control. The highest inhibition (66.91%) was exhibited by the 400 mg/kg/day dose of 80% methanolic crude extract. Among the fractions, chloroform fraction demonstrated maximal chemosuppressive effect (55.60%). Moreover, crude extracts and solvent fractions prevented body weight loss, reduction in temperature, and anemia compared to the negative control. Except the aqueous fraction, the tested plant extracts were able to significantly prolong the survival time of infected mice.
The findings of the present study confirmed the safety and a promising antimalarial activity of , thus supporting the traditional claim and efficacy. In-depth investigations on the plant, however, are highly recommended. antimalarial activity of the plant was investigated. against antiplasmodial activity. In the present study, the.
疟疾是导致死亡和发病的主要原因之一。此外，抗疟药物耐药性的出现是控制该疾病的一个主要问题。这使得开发新型抗疟药物成为必要。药用植物是发现抗疟药物的重要来源。在埃塞俄比亚民间医学中，[植物名称]因其抗疟作用而闻名，并具有抗疟原虫活性。在本研究中，对该植物的抗疟活性进行了研究。
采用标准程序进行急性毒性试验。为筛选该植物对伯氏疟原虫（ANKA）的抗疟活性，采用了4天抑制试验。提取物和馏分以100、200和400mg/kg/天的剂量连续4天通过口服灌胃给予感染小鼠。然后评估诸如寄生虫血症等参数。
口服急性毒性试验中未观察到任何毒性迹象。与阴性对照相比，粗提物和溶剂馏分对寄生虫载量有显著（P<0.05）抑制作用。80%甲醇粗提物400mg/kg/天剂量表现出最高抑制率（66.91%）。在馏分中，氯仿馏分表现出最大的化学抑制作用（55.60%）。此外，与阴性对照相比，粗提物和溶剂馏分可防止体重减轻、体温降低和贫血。除水相馏分外，受试植物提取物能够显著延长感染小鼠的存活时间。
本研究结果证实了[植物名称]的安全性和有前景的抗疟活性，从而支持了传统说法和疗效。然而，强烈建议对该植物进行深入研究。对该植物的抗疟活性进行了研究。对其抗疟原虫活性进行了研究。在本研究中，[植物名称]的……
