Department for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.
Department of Drug Chemistry and Technology, Sapienza University, 00185 Rome, Italy.
Molecules. 2020 Apr 23;25(8):1977. doi: 10.3390/molecules25081977.
(L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of L. male and female plants were investigated for the antimicrobial activity. Leaf extracts were tested on microbes , , , , and . Furthermore, the extracts showing antimicrobial activity were fractionated by LPCC and the obtained fractions tested on the same microorganism strains. Positive fractions were investigated by gas-chromatography/mass spectrometry (GC-MS) and were seen to be rich in sesquiterpenes, sesquiterpenoids and other terpens. The obtained effects highlighted the antimicrobial properties of (L.) leaf compounds and revealed their importance as a source of bioactive molecules of potential pharmaceutical interest. To our knowledge, this is the first paper reporting investigations on the chemical composition of the extracts and derived positive fractions from (L.) plants grown in central Italy.
(L.) 是漆树科的雌雄异株植物，原产于南美洲，目前在世界许多地区广泛分布。在这项工作中，研究了雄性和雌性 L.植物的叶提取物及其衍生的低压柱层析 (LPCC) 馏分的抗菌活性。叶提取物在微生物 、 、 、 、 上进行了测试。此外，表现出抗菌活性的提取物通过 LPCC 进行了分馏，得到的馏分在相同的微生物菌株上进行了测试。阳性馏分通过气相色谱/质谱 (GC-MS) 进行了研究，结果表明它们富含倍半萜、倍半萜类化合物和其他萜类化合物。所获得的效果突出了 (L.) 叶化合物的抗菌特性，并揭示了它们作为具有潜在药物应用的生物活性分子的重要来源。据我们所知，这是第一篇报道在意大利中部生长的 (L.) 植物的提取物及其衍生的阳性馏分的化学成分研究的论文。
