Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Nanomedicine. 2020 Jun;26:102175. doi: 10.1016/j.nano.2020.102175. Epub 2020 Mar 6.
Liquid metals in recent years have grabbed the attention of researchers due to their expanded applicability not only in the field of therapeutics but also in theranostic. Acknowledged as a nuclear medicine due to its radioactivity, Gallium finds its widespread application in disorders of bone, calcium metabolism, and cancer. The present article deals with the advancement of gallium based nanoplatforms for therapy, imaging, and biosensing of cancers. The article describes the gallium based nanoconjugates and furnishes one's understanding of various therapeutic approaches such as photothermal therapy, sonodynamic therapy, radiotherapy, and immunotherapy along with various imaging platforms and biosensing platforms. A brief section related to patents on gallium based nanoplatforms in cancer has been included along with various molecular docking and simulation studies done on gallium. The recent advancement with respect to drug delivery gives an insight into the future perspective of gallium based nanoplatforms in the field of cancer theranostic.
近年来，液态金属因其在治疗领域的扩展应用而引起了研究人员的关注，不仅如此，它在治疗诊断学领域也有应用。由于其放射性，镓被认为是一种核医学药物，在骨骼疾病、钙代谢和癌症方面有广泛的应用。本文介绍了基于镓的纳米平台在癌症的治疗、成像和生物传感方面的进展。本文描述了基于镓的纳米复合物，并提供了对各种治疗方法的理解，如光热疗法、声动力学疗法、放射疗法和免疫疗法，以及各种成像平台和生物传感平台。本文还包括了与癌症相关的基于镓的纳米平台的专利的简要部分，以及对镓的各种分子对接和模拟研究。关于药物输送的最新进展让我们深入了解了基于镓的纳米平台在癌症治疗诊断学领域的未来前景。
