Danchin Antoine
AMAbiotics SAS, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014, Paris, France.
Microb Biotechnol. 2020 Jul;13(4):895-898. doi: 10.1111/1751-7915.13549. Epub 2020 Mar 9.
Even when they no longer require the presence of iron, cells use zinc as a divalent cation, involved in a large variety of catalytic and regulatory functions. This metal is so important that it appears that ribosomes are instrumental in its ultimate storage. Here, we summarize a detailed analysis which investigates the way the global cell metabolism is integrated by zinc. This integration results from the zinc-dependent way in which the one-carbon metabolism is always coupled to the translation process, not only via methionine and S-adenosylmethionine, but via the complex set-up of the modification of the position 34 of the anticodon of tRNAs.
即使细胞不再需要铁的存在，它们也会将锌用作二价阳离子，参与多种催化和调节功能。这种金属非常重要，以至于核糖体似乎在其最终储存中发挥着作用。在这里，我们总结了一项详细分析，该分析研究了锌整合全球细胞代谢的方式。这种整合源于一碳代谢始终与翻译过程耦合的锌依赖性方式，不仅通过甲硫氨酸和S-腺苷甲硫氨酸，而且通过tRNA反密码子第34位修饰的复杂机制。
