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基于深度卷积神经网络的半月板撕裂检测:与放射科医生和手术作为金标准的比较。

Deep convolutional neural network-based detection of meniscus tears: comparison with radiologists and surgery as standard of reference.

机构信息

Department of Radiology, Balgrist University Hospital, Forchstrasse 340, CH-8008, Zurich, Switzerland.

Faculty of Medicine, University of Zurich, Zurich, Switzerland.

出版信息

Skeletal Radiol. 2020 Aug;49(8):1207-1217. doi: 10.1007/s00256-020-03410-2. Epub 2020 Mar 13.

Abstract

OBJECTIVE

To clinically validate a fully automated deep convolutional neural network (DCNN) for detection of surgically proven meniscus tears.

MATERIALS AND METHODS

One hundred consecutive patients were retrospectively included, who underwent knee MRI and knee arthroscopy in our institution. All MRI were evaluated for medial and lateral meniscus tears by two musculoskeletal radiologists independently and by DCNN. Included patients were not part of the training set of the DCNN. Surgical reports served as the standard of reference. Statistics included sensitivity, specificity, accuracy, ROC curve analysis, and kappa statistics.

RESULTS

Fifty-seven percent (57/100) of patients had a tear of the medial and 24% (24/100) of the lateral meniscus, including 12% (12/100) with a tear of both menisci. For medial meniscus tear detection, sensitivity, specificity, and accuracy were for reader 1: 93%, 91%, and 92%, for reader 2: 96%, 86%, and 92%, and for the DCNN: 84%, 88%, and 86%. For lateral meniscus tear detection, sensitivity, specificity, and accuracy were for reader 1: 71%, 95%, and 89%, for reader 2: 67%, 99%, and 91%, and for the DCNN: 58%, 92%, and 84%. Sensitivity for medial meniscus tears was significantly different between reader 2 and the DCNN (p = 0.039), and no significant differences existed for all other comparisons (all p ≥ 0.092). The AUC-ROC of the DCNN was 0.882, 0.781, and 0.961 for detection of medial, lateral, and overall meniscus tear. Inter-reader agreement was very good for the medial (kappa = 0.876) and good for the lateral meniscus (kappa = 0.741).

CONCLUSION

DCNN-based meniscus tear detection can be performed in a fully automated manner with a similar specificity but a lower sensitivity in comparison with musculoskeletal radiologists.

摘要

目的

临床验证一种全自动深度卷积神经网络(DCNN)在检测手术证实的半月板撕裂中的应用。

材料与方法

回顾性纳入 100 例连续患者,这些患者在我院接受膝关节 MRI 和膝关节镜检查。两名肌肉骨骼放射科医生和 DCNN 独立评估所有 MRI 以检测内侧和外侧半月板撕裂。纳入的患者不在 DCNN 的训练集中。手术报告作为参考标准。统计数据包括敏感性、特异性、准确性、ROC 曲线分析和kappa 统计。

结果

57%(57/100)的患者有内侧半月板撕裂,24%(24/100)的患者有外侧半月板撕裂,包括 12%(12/100)的患者有两个半月板撕裂。对于内侧半月板撕裂检测,读者 1 的敏感性、特异性和准确性分别为 93%、91%和 92%,读者 2 为 96%、86%和 92%,DCNN 为 84%、88%和 86%。对于外侧半月板撕裂检测,读者 1 的敏感性、特异性和准确性分别为 71%、95%和 89%,读者 2 为 67%、99%和 91%,DCNN 为 58%、92%和 84%。读者 2 与 DCNN 检测内侧半月板撕裂的敏感性差异有统计学意义(p=0.039),而其他所有比较的差异均无统计学意义(均 p≥0.092)。DCNN 检测内侧、外侧和总体半月板撕裂的 AUC-ROC 分别为 0.882、0.781 和 0.961。内侧半月板的读者间一致性非常好(kappa=0.876),外侧半月板的读者间一致性良好(kappa=0.741)。

结论

与肌肉骨骼放射科医生相比,基于 DCNN 的半月板撕裂检测可以全自动进行,具有相似的特异性,但敏感性较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc0/7299917/60bfc94174b6/256_2020_3410_Fig1_HTML.jpg

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