Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.
Cardiovasc Res. 2021 Feb 22;117(3):663-673. doi: 10.1093/cvr/cvaa062.
Heterogeneous macrophage lineages are present in the aortic and mitral valves of the heart during development and disease. These populations include resident macrophages of embryonic origins and recruited monocyte-derived macrophages prevalent in disease. Soon after birth, macrophages from haematopoietic lineages are recruited to the heart valves, and bone marrow transplantation studies in mice demonstrate that haematopoietic-derived macrophages continue to invest adult valves. During myxomatous heart valve disease, monocyte-derived macrophages are recruited to the heart valves and they contribute to valve degeneration in a mouse model of Marfan syndrome. Here, we review recent studies of macrophage lineages in heart valve development and disease with discussion of clinical significance and therapeutic applications.
在心脏发育和疾病过程中，主动脉瓣和二尖瓣存在异质性的巨噬细胞谱系。这些群体包括胚胎来源的固有巨噬细胞和在疾病中普遍存在的募集而来的单核细胞衍生的巨噬细胞。出生后不久，造血谱系的巨噬细胞就被招募到心脏瓣膜，并且在小鼠的骨髓移植研究中表明，造血衍生的巨噬细胞持续浸润成年瓣膜。在黏液样心脏瓣膜病中，单核细胞衍生的巨噬细胞被招募到心脏瓣膜，并且它们在马凡综合征的小鼠模型中导致瓣膜退化。在这里，我们回顾了心脏瓣膜发育和疾病中巨噬细胞谱系的最新研究，并讨论了其临床意义和治疗应用。
