Hiramatsu Kohzy
Laboratory of Animal Functional Anatomy (LAFA), Faculty of Agriculture, Shinshu University, Minami-minowa 8304, Kami-ina, Nagano 399-4598, Japan.
J Poult Sci. 2020 Jan 25;57(1):1-6. doi: 10.2141/jpsa.0190003.
Many types of endocrine cells have been identified in the gastroenteropancreatic system of vertebrates, which have subsequently been named with alphabet (s). L cells which secrete the glucagon-like peptide (GLP)-1 are scattered in the intestinal epithelium. This review discusses the morphological features of chicken L cells and GLP-1 secretion from intestinal L cells. L cells, identified using GLP-1 immunohistochemistry, are open-type endocrine cells that are distributed in the jejunum and ileum of chickens. GLP-1 co-localizes with GLP-2 and neurotensin in the same cells of the chicken ileum. Intestinal L cells secrete GLP-1 in response to food ingestion. Proteins and amino acids, such as lysine and methionine, in the diet trigger GLP-1 secretion from the chicken intestinal L cells. The receptor that specifically binds chicken GLP-1 is expressed in pancreatic D cells, implying that the physiological functions of chicken GLP-1 differ from its functions as an incretin in mammals.
在脊椎动物的胃肠胰系统中已鉴定出多种类型的内分泌细胞，这些细胞随后按字母顺序命名。分泌胰高血糖素样肽（GLP）-1的L细胞散布于肠上皮中。本文综述了鸡L细胞的形态特征以及肠L细胞分泌GLP-1的情况。利用GLP-1免疫组织化学鉴定出的L细胞是开放型内分泌细胞，分布于鸡的空肠和回肠。在鸡回肠的同一细胞中，GLP-1与GLP-2和神经降压素共定位。肠L细胞在摄入食物后分泌GLP-1。日粮中的蛋白质和氨基酸，如赖氨酸和蛋氨酸，可触发鸡肠L细胞分泌GLP-1。特异性结合鸡GLP-1的受体在胰腺D细胞中表达，这意味着鸡GLP-1的生理功能与其作为哺乳动物肠促胰岛素的功能不同。
