Fang Jing, Pan Long, Gu Qiu-Xia, Juengpanich Sarun, Zheng Jun-Hao, Tong Chen-Hao, Wang Zi-Yuan, Nan Jun-Jie, Wang Yi-Fan
Key Laboratory of Laparoscopic Technique Research of Zhejiang Province, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Zhejiang Province Medical Research Center of Minimally Invasive Diagnosis and Treatment of Abdominal Diseases, Hangzhou 310016, China.
Ann Transl Med. 2020 Feb;8(4):93. doi: 10.21037/atm.2019.12.110.
The mTOR pathway is vital for homeostasis, metabolism, cancer transplantation and regeneration in the liver. The aim of this study is to use a bibliometric method to reveal current research hotspots and promising future trends in mTOR signaling in liver diseases.
Publications were searched and downloaded from the Web of Science Core Collection (WOSCC) Database. CiteSpace, Carrot2, and VOSviewer programs were utilized to analyze the contribution of various countries/regions, institutes, and authors; and to reveal research hotspots and promising future trends in this research area.
Until May 21, 2019, a total of 2,232 papers regarding mTOR signaling pathway in liver disease were included, and each paper was cited 23.21 times on average. The most active country was the USA. 5 landmark articles with centrality and burstiness were determined by co-citation analysis. Research hotspots included "liver transplantation" "hepatic stellate cell proliferation" "NAFLD" "therapy of HCC". Moreover, six key clusters were discovered during the procedure of "clustering", including "liver transplantation" "protein synthesis" "mTOR inhibitor" "following early cyclosporine withdrawal" "srebp-1 activation", and "hepatocellular cancer".
Various scientific methods were applied to reveal scientific productivity, collaboration, and research hotspots in the mTOR signaling pathway in liver disease. Liver transplantation, hepatic stellate cell proliferation, non-alcoholic fatty liver disease (NAFLD), therapy of hepatocellular carcinoma (HCC), cell growth and autophagy, are research hotspots and are likely to be promising in the next few years. Further studies in this field are needed.
mTOR信号通路对肝脏的内环境稳定、新陈代谢、癌症移植及再生至关重要。本研究旨在运用文献计量学方法揭示肝脏疾病中mTOR信号传导的当前研究热点及未来潜在趋势。
从Web of Science核心合集（WOSCC）数据库检索并下载出版物。利用CiteSpace、Carrot2和VOSviewer程序分析不同国家/地区、机构及作者的贡献；并揭示该研究领域的研究热点及未来潜在趋势。
截至2019年5月21日，共纳入2232篇关于肝脏疾病中mTOR信号通路的论文，每篇论文平均被引用23.21次。最活跃的国家是美国。通过共被引分析确定了5篇具有中心性和突发性的标志性文章。研究热点包括“肝移植”“肝星状细胞增殖”“非酒精性脂肪性肝病（NAFLD）”“肝癌治疗”。此外，在“聚类”过程中发现了六个关键聚类，包括“肝移植”“蛋白质合成”“mTOR抑制剂”“早期停用环孢素后”“固醇调节元件结合蛋白-1（SREBP-1）激活”以及“肝细胞癌”。
应用多种科学方法揭示了肝脏疾病中mTOR信号通路的科研产出、合作情况及研究热点。肝移植、肝星状细胞增殖、非酒精性脂肪性肝病（NAFLD）、肝细胞癌（HCC）治疗、细胞生长和自噬是研究热点，且在未来几年可能具有前景。该领域需要进一步研究。
