Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, Germany.
Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, UC San Diego, La Jolla, CA, 92037, United States.
Sci Rep. 2020 Mar 16;10(1):4816. doi: 10.1038/s41598-020-61706-8.
To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70-1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47-0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.
为了调查在视力相对较好的大型欧洲队列中，年龄相关性黄斑变性（AMD）患者中抑郁和焦虑的发生率和新发病例及其与 AMD 的关系。本研究纳入了德国基于人群的哥廷根健康研究中的 11834 名参与者。通过眼底照片分级诊断 AMD。分别用患者健康问卷和广泛性焦虑障碍-2 量表评估抑郁和焦虑。进行了逻辑回归分析，并调整了几个参数。1089 名（9.2%）参与者被诊断患有 AMD。AMD 和非 AMD 参与者的抑郁患病率分别为 7.2%和 8.0%，焦虑患病率分别为 4.2%和 7.0%。AMD 患者在 5 年随访期间新发抑郁和焦虑的比例分别为 2.6%和 3.6%。AMD 与抑郁无关（OR 0.93；95%CI 0.70-1.20；p=0.62）。AMD 与较少的焦虑相关（OR 0.67；95%CI 0.47-0.93；p=0.02）。这是第一项分析 AMD 患者中抑郁和焦虑的发生率和新发病例的研究。在我们的基于人群的样本中，AMD 和非 AMD 参与者的抑郁发生率和新发病例相似。无 AMD 的参与者焦虑发生率较高。AMD 与抑郁无关。
