Faculty of Medicinal Plants, Department of Basic and Science, Amol University of Special Modern Technologies, Amol, Iran.
Department of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran.
Crit Rev Food Sci Nutr. 2021;61(3):522-534. doi: 10.1080/10408398.2020.1738999. Epub 2020 Mar 17.
One of the emerging and recent strategies to combat cancer is application of natural bioactive compounds and phytochemicals. Carotenoids including lycopene, -carotene, astaxanthin, crocin, -cryptoxanthin, and lutein, are the main group of plant pigments which play important roles in the prevention and healing process of different diseases including cancer. The pharmacological use of carotenoid compounds is frequently limited by their low bioavailability and solubility as they are mainly lipophilic compounds. The present study focuses on the current data on formulation of different carotenoid nanodelivery systems for cancer therapy and a brief overview of the obtained results. Encapsulation of carotenoids within different nanocarriers is a remarkable approach and innovative strategy for the improvement of health-promoting features and particularly, cancer prevention/treatment roles of these compounds through enhancing their solubility, cellular uptake, membrane permeation, bioaccessibility, and stability. There is various nanocarrier for loading carotenoids including polymeric/biopolymeric, lipid-based, inorganic, and hybrid nanocarriers. Almost in all relevant studies, these nano delivery systems have shown promising results in improving the efficiency of carotenoids in cancer therapy. [Formula: see text].
对抗癌症的新兴策略之一是应用天然生物活性化合物和植物化学物质。类胡萝卜素包括番茄红素、β-胡萝卜素、虾青素、藏红花素、β-隐黄质和叶黄素，是植物色素的主要群体，它们在预防和治疗各种疾病（包括癌症）方面发挥着重要作用。由于类胡萝卜素化合物主要是脂溶性化合物，其生物利用度和溶解度较低，因此其药理学用途经常受到限制。本研究重点介绍了目前关于不同类胡萝卜素纳米递药系统用于癌症治疗的研究数据，并简要概述了所获得的结果。将类胡萝卜素包封在不同的纳米载体中是一种显著的方法和创新策略，可通过提高其溶解度、细胞摄取、膜渗透、生物利用度和稳定性来增强这些化合物的促进健康的特性，特别是预防/治疗癌症的作用。有多种纳米载体可用于负载类胡萝卜素，包括聚合物/生物聚合物、基于脂质的、无机和杂化纳米载体。在几乎所有相关研究中，这些纳米递药系统在提高类胡萝卜素在癌症治疗中的效率方面都显示出了有希望的结果。[公式：见正文]。
